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Anlotinib (hydrochloride)

Catalog No.GC45677

A neuropeptide with diverse biological activities

Products are for research use only. Not for human use. We do not sell to patients.

Anlotinib (hydrochloride) Chemical Structure

Cas No.: N/A

Size Price Stock Qty
1mg
$47.00
In stock
5mg
$204.00
In stock
10mg
$384.00
In stock
25mg
$780.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Anlotinib is an orally bioavailable tyrosine kinase inhibitor that inhibits human VEGFR1, VEGFR2, VEGFR3, PDGFRβ, and c-Kit (IC50s = 26.9, 0.2, 0.7, 115, and 14.8 nM, respectively).1 It is selective for these kinases over c-Met, c-Src, HER2, and EGFR (IC50s = >2,000 nM). It also inhibits FGFR1 (IC50 = 11.7 nM for the human receptor).2 Anlotinib inhibits the growth of SW620 and HT-29 colorectal, 786-O and Caki-1 renal, A549 and NCI H526 lung, MDA-MB-231 breast, HMC-1 leukemia, A375 melanoma, and U-87 MG glioblastoma cancer cells (IC50s = 3-12.5 μM).1 It inhibits VEGF-induced migration (IC50 = 0.1 nM) and FBS-induced tube formation in human umbilical vein endothelial cells (HUVECs). Anlotinib (1.5 nmol) inhibits VEGF-induced angiogenesis in a chicken chorioallantoic membrane (CAM) assay.2 It also decreases tumor volume by 83% and tumor angiogenesis by 91.2% in a SW620 xenograft mouse model when administered at a dose of 3 mg/kg per day.1

|1. Xie, C., Wan, X., Quan, H., et al. Preclinical characterization of anlotinib, a highly potent and selective vascular endothelial growth factor receptor-2 inhibitor. Cancer Sci. 109(4), 1207-1219 (2018).|2. Lin, B., Song, X., Yang, D., et al. Anlotinib inhibits angiogenesis via suppressing the activation of VEGFR2, PDGFRβ and FGFR1. Gene 654, 77-86 (2018).

Chemical Properties

Cas No. N/A SDF
Canonical SMILES COC1=C(OCC2(N)CC2)C=C3C(C(OC4=C(F)C5=C(NC(C)=C5)C=C4)=CC=N3)=C1.Cl
Formula C23H22FN3O3.HCl M.Wt 443.9
Solubility DMF: 0.5mg/mL,DMSO: 1mg/mL,DMSO:PBS (pH 7.2) (1:3): 0.25mg/mL Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.2528 mL 11.2638 mL 22.5276 mL
5 mM 0.4506 mL 2.2528 mL 4.5055 mL
10 mM 0.2253 mL 1.1264 mL 2.2528 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for Anlotinib (hydrochloride)

Average Rating: 5 ★★★★★ (Based on Reviews and 33 reference(s) in Google Scholar.)

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