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AP1189 acetate

(Synonyms: AP-1189; AP 1189; AP1189; AP1189 acetate;) Catalog No.: GB62274

AP1189 is a biased agonist at receptors MC1 and MC3.

Products are for research use only. Not for human use. We do not sell to patients.

AP1189 acetate Chemical Structure

Cas No.:959850-74-9

Size Price Stock Qty
5mg
$150.00
In stock
10mg
$250.00
In stock
25mg
$450.00
In stock
50mg
$750.00
In stock
100mg
$1,250.00
In stock
200mg
$1,950.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

AP1189 is a biased agonist at receptors MC1 and MC3. AP1189 reduced cytokine release, an effect reliant on both MC1 and MC3 as evident from the use of Mc1r(-/-) and Mc3r(-/-) macrophages. No melanogenesis was induced by AP1189 in B16-F10 melanocytes. In vivo, oral AP1189 elicited anti-inflammatory actions in peritonitis and, upon administration at the peak of inflammation, accelerated the resolution phase by ∼3-fold.

Chemical Properties

Cas No. 959850-74-9 SDF
Synonyms AP-1189; AP 1189; AP1189; AP1189 acetate;
Canonical SMILES NC(N/N=C/C=C/C1=CC=CN1C2=CC=CC=C2[N+]([O-])=O)=N.CC(O)=O
Formula C16H18N6O4 M.Wt 358.36
Solubility Soluble in DMSO Storage Store at -20℃
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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