Apatinib-d8 |
| Catalog No.GC49799 |
An internal standard for the quantification of apatinib
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2468771-43-7
Sample solution is provided at 25 µL, 10mM.
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Apatinib-d8 is intended for use as an internal standard for the quantification of apatinib by GC- or LC-MS. Apatinib is a tyrosine kinase inhibitor that potently suppresses the kinase activity of vascular endothelial growth factor 2 (VEGFR2; IC50 = 1 nM).1 It is less effective against c-Kit (IC50 = 429 nM), RET (IC50 = 13 nM), and c-Src (IC50 = 53 nM) and does not inhibit EGFR, HER2, or FGFR1 (IC50s = >10 µM).1 Apatinib has been shown to inhibit the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs) stimulated by fetal bovine serum and, either alone or in combination with chemotherapeutic agents, prevents the growth of several established human tumor xenograft models.1
1.Tian, S., Quan, H., Xie, C., et al.YN968D1 is a novel and selective inhibitor of vascular endothelial growth factor receptor-2 tyrosine kinase with potent activity in vitro and in vivoCancer Sci.102(7)1374-1380(2011)
Average Rating: 5 (Based on Reviews and 22 reference(s) in Google Scholar.)
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