AR-C 118925XX |
| Catalog No.GC50081 |
Selective and competitive P2Y2 antagonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 216657-60-2
Sample solution is provided at 25 µL, 10mM.
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Selective, competitive P2Y2 receptor antagonist. Inactive against a panel of 37 other receptors at a concentration of 10 μM. Inhibits ATP-γS-induced mucin secretion in bronchial epithelial cells (IC50 = 1 μM). Inhibits P2Y2 receptor-induced β-arrestin translocation in vitro (pA2 = 37.2-51.3 nM).
Kemp et al (2004) Nucleotide-mediated mucin secretion from differentiated human bronchial epithelial cells. Am.J.Respir.Cell Mol.Biol. 31 446 PMID:15231488 |Meghani (2002) The design of P2Y2 antagonists for the treatment of inflammatory diseases. Abstract of papers, 224th ACS National Meeting, Boston, MA |Rafehi et al (2017) Synthesis, characterization, and in vitro evaluation of the selective P2Y2 receptor antagonist AR-C118925. Purinergic.Signal. 13 89 PMID:27766552
Average Rating: 5 (Based on Reviews and 5 reference(s) in Google Scholar.)
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