1,2,3,4,6-pentagalloylglucose |
| رقم الكتالوجGN10059 |
1,2,3,4,6-pentagalloylglucose(Pentagalloylglucose; PGG) is a polyphenolic compound with powerful antioxidant, anti-inflammatory, antibacterial, antiviral, and antitumor effects.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 14937-32-7
Sample solution is provided at 25 µL, 10mM.
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1,2,3,4,6-pentagalloylglucose(Pentagalloylglucose;PGG) is a polyphenolic compound with powerful antioxidant, anti-inflammatory, antibacterial, antiviral, and antitumor effects [1-2]. 1,2,3,4,6-pentagalloylglucose is a potent and cellular active inhibitor of the PALB2-BRCA2 protein-protein interaction (PPI). 1,2,3,4,6-pentagalloylglucose binds PALB2 at the BRCA2 binding site and significantly suppresses HR repair by inhibiting BRCA2 recruitment to the DNA damage site.
1,2,3,4,6-pentagalloylglucose (5, 10, or 20µM; 1h) blocked cGAS-STING pathway activation in bone marrow-derived macrophages (BMDMs) in vitro[3]. 1,2,3,4,6-pentagalloylglucose (10μM; 4h) suppresses HR-mediated DNA repair in U2OS cells[4]. 1,2,3,4,6-pentagalloylglucose (0-60µM; 24h) dose-dependently inhibited the proliferation of CNE1 and CNE2 cells. PGG regulated the cell cycle by altering p53, cyclin D1, CDK2, and cyclin E1 protein levels[5].
1,2,3,4,6-pentagalloylglucose (20 and 40mg/kg; i.p) treatment significantly reduced the alanine aminotransferase (ALT), aspartate aminotransferase (AST), and alkaline phosphatase (ALP) levels in mice with AILI, and protect Acetaminophen-induced acute liver injury in mice[3]. Pre-treatment with 1,2,3,4,6-pentagalloylglucose (5 and 10mg/kg; i.p; 7days) showed significant, and dose dependent protection against I/R-induced brain injury by alleviating all the behavioral, neurological, morphological, and histological changes induced by I/R. The protective effect of 1,2,3,4,6-pentagalloylglucose is thought to be due to its powerful antioxidant properties[6].
References:
[1]. Ashibe S, Ikeuchi K, et,al. Non-Enzymatic Oxidation of a Pentagalloylglucose Analogue into Members of the Ellagitannin Family. Angew Chem Int Ed Engl. 2017 Nov 27;56(48):15402-15406. doi: 10.1002/anie.201708703. Epub 2017 Nov 2. PMID: 29024258.
[2]. Mikolajczyk TP, Nosalski R, et,al. 1,2,3,4,6-Penta-O-galloyl-β-d-glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II-induced hypertension. Br J Pharmacol. 2019 Jun;176(12):1951-1965. doi: 10.1111/bph.14583. Epub 2019 Mar 14. PMID: 30658013; PMCID: PMC6534792.
[3]. Zheng C, Chen Y, et,al. Pentagalloylglucose alleviates acetaminophen-induced acute liver injury by modulating inflammation via cGAS-STING pathway. Mol Med. 2024 Sep 27;30(1):160. doi: 10.1186/s10020-024-00924-6. PMID: 39333876; PMCID: PMC11428449.
[4]. Zeng J, Han J, et,al. Pentagalloylglucose disrupts the PALB2-BRCA2 interaction and potentiates tumor sensitivity to PARP inhibitor and radiotherapy. Cancer Lett. 2022 Oct 10;546:215851. doi: 10.1016/j.canlet.2022.215851. Epub 2022 Aug 1. PMID: 35926819.
[5]. Fan CW, Tang J, et,al. Pentagalloylglucose suppresses the growth and migration of human nasopharyngeal cancer cells via the GSK3β/β-catenin pathway in vitro and in vivo. Phytomedicine. 2022 Jul 20;102:154192. doi: 10.1016/j.phymed.2022.154192. Epub 2022 May 21. PMID: 35636179.
[6]. Viswanatha GL, Shylaja H, et,al. Alleviation of transient global ischemia/reperfusion-induced brain injury in rats with 1,2,3,4,6-penta-O-galloyl-β-d-glucopyranose isolated from Mangifera indica. Eur J Pharmacol. 2013 Nov 15;720(1-3):286-93. doi: 10.1016/j.ejphar.2013.10.016. Epub 2013 Oct 22. PMID: 24157980.
| Cell experiment [1]: | |
Cell lines | Bone marrow-derived macrophages (BMDMs) |
Preparation Method | BMDMs were pretreated with 1,2,3,4,6-pentagalloylglucose (5, 10, or 20µM) for 1h and then stimulated with the cGAS agonist interferon stimulatory DNA (ISD) to model cGAS-STING activation. |
Reaction Conditions | 5, 10, or 20µM; 1h |
Applications | 1,2,3,4,6-pentagalloylglucose inhibits cGAS-STING pathway activation in BMDMs. |
| Animal experiment [1]: | |
Animal models | C57BL/6 mice(Acetaminophen-induced liver injury (AILI)) |
Preparation Method | Mice were fasted with water for 12h. Except for the control group, which was administered the corresponding volume of solvent, each group was injected intraperitoneally with 400mg/kg Acetaminophen dissolved in warm saline, and then injected with 20 and 40mg/kg 1,2,3,4,6-pentagalloylglucose 1h later. The mice were sacrificed after 24h, and serum and liver tissues were collected. |
Dosage form | 20 and 40mg/kg; i.p |
Applications | 1,2,3,4,6-pentagalloylglucose protect Acetaminophen-induced acute liver injury in mice. |
References: | |
| Cas No. | 14937-32-7 | SDF | |
| Chemical Name | [(2R,3R,4S,5R,6S)-3,4,5,6-tetrakis[(3,4,5-trihydroxybenzoyl)oxy]oxan-2-yl]methyl 3,4,5-trihydroxybenzoate | ||
| Canonical SMILES | C1=C(C=C(C(=C1O)O)O)C(=O)OCC2C(C(C(C(O2)OC(=O)C3=CC(=C(C(=C3)O)O)O)OC(=O)C4=CC(=C(C(=C4)O)O)O)OC(=O)C5=CC(=C(C(=C5)O)O)O)OC(=O)C6=CC(=C(C(=C6)O)O)O | ||
| Formula | C41H32O26 | M.Wt | 940.68 |
| الذوبان | ≥ 50.4mg/mL in DMSO | Storage | Store at 2-8°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.0631 mL | 5.3153 mL | 10.6306 mL |
| 5 mM | 0.2126 mL | 1.0631 mL | 2.1261 mL |
| 10 mM | 0.1063 mL | 0.5315 mL | 1.0631 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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