الصفحة الرئيسية>>Signaling Pathways>> Cancer Biology>>1,2,3,4-Tetrahydrostaurosporine

1,2,3,4-Tetrahydrostaurosporine (Synonyms: AFN-941)

رقم الكتالوجGC46039

A mutant EGFR inhibitor

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1,2,3,4-Tetrahydrostaurosporine التركيب الكيميائي

Cas No.: 220038-19-7

الحجم السعر المخزون الكميّة
1mg
796٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of 1,2,3,4-Tetrahydrostaurosporine

1,2,3,4-Tetrahydrostaurosporine is a derivative of staurosporine and an inhibitor of mutant EGFR (IC50 = 74 nM for EGFRT790M).1 It is selective for EGFRT790M over wild-type EGFR (IC50 = 390 nM). It also binds to Janus kinase 3 (JAK3).2

|1. Song, X., Liu, X., and Ding, X. Staurosporine scaffold-based rational discovery of the wild-type sparing reversible inhibitors of EGFR T790M gatekeeper mutant in lung cancer with analog-sensitive kinase technology. J. Mol. Recognit. 30(4), (2017).|2. Boggon, T.J., Li, Y., Manley, P.W., et al. Crystal structure of the Jak3 kinase domain in complex with a staurosporine analog. Blood 106(3), 996-1002 (2005).

Chemical Properties of 1,2,3,4-Tetrahydrostaurosporine

Cas No. 220038-19-7 SDF
المرادفات AFN-941
Canonical SMILES [H][C@]12N(C3=C4C5=C(CNC5=O)C6=C3N([C@](O2)(C)[C@H](OC)[C@H](NC)C1)C7=CC=CC=C76)C8=C4CCCC8
Formula C28H30N4O3 M.Wt 470.6
الذوبان Acetone: slightly soluble,DMSO: slightly soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 1,2,3,4-Tetrahydrostaurosporine

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.1249 mL 10.6247 mL 21.2495 mL
5 mM 0.425 mL 2.1249 mL 4.2499 mL
10 mM 0.2125 mL 1.0625 mL 2.1249 mL
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In vivo Formulation Calculator (Clear solution) of 1,2,3,4-Tetrahydrostaurosporine

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 38 reference(s) in Google Scholar.)

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