1,2,3-Trioleoyl Glycerol-d5 (Synonyms: Glyceryl Trioleate-d5; TG(18:1/18:1/18:1)-d5; Triolein-d5) |
| رقم الكتالوجGC92074 |
الغرض من 1,2,3-Trioleoyl Glycerol-d5 هو استخدامه كمعيار داخلي لقياس كمية 1،2،3-trioleoyl glycerol بواسطة GC أو LC-MS.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 60892-83-3
Sample solution is provided at 25 µL, 10mM.
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1,2,3-Trioleoyl glycerol-d5 is intended for use as an internal standard for the quantification of 1,2,3-trioleoyl glycerol by GC- or LC-MS. 1,2,3-Trioleoyl glycerol is a triacylglycerol that contains oleic acid at the sn-1, sn-2, and sn-3 positions. It inhibits oxidized LDL-induced decreases in cell viability and superoxide dismutase (SOD) and glutathione peroxidase (GPX) activities and increases in apoptosis in endothelial cells when used at a concentration of 10 μM.1 1,2,3-Trioleoyl glycerol has been found in sunflower, corn, and extra virgin olive oils.2,3 It has been used as a standard for the quantification of triacylglycerols in extra virgin olive oil by high-temperature gas chromatography-(ionic trap)mass spectrometry (HTGC-(IT)MS).3 1,2,3-Trioleoyl glycerol is a major component of Lorenzo's oil.4
References:
[1]. Luo, T., Deng, Z.Y., Li, X.P., et al.Triolein and trilinolein ameliorate oxidized low-density lipoprotein-induced oxidative stress in endothelial cellsLipids49(5)495-504(2014).
[2]. Gao, B., Luo, Y., Lu, W., et al.Triacylglycerol compositions of sunflower, corn and soybean oils examined with supercritical CO2 ultra-performance convergence chromatography combined with quadrupole time-of-flight mass spectrometryFood Chem.218569-574(2017).
[3]. Ruiz-Samblás, C., Rodríguez-Cuadros, L., González-Casado, A., et al.A straightforward quantification of triacylglycerols (and fatty acids) in monovarietal extra virgin olive oils by high-temperature GCAnal. Methods4(3)753-758(2012).
[4]. Moser, H.W., Moser, A.B., Hollandsworth, K., et al."Lorenzo's oil" therapy for X-linked adrenoleukodystrophy: Rationale and current assessment of efficacyJ. Mol. Neurosci.33(1)105-113(2007).
| Cas No. | 60892-83-3 | SDF | |
| المرادفات | Glyceryl Trioleate-d5; TG(18:1/18:1/18:1)-d5; Triolein-d5 | ||
| Chemical Name | 9Z-octadecenoic acid, 1,2,3-propanetriyl-1,1,2,3,3-d5 ester | ||
| Canonical SMILES | O=C(CCCCCCC/C=C\CCCCCCCC)OC([2H])([2H])C(OC(CCCCCCC/C=C\CCCCCCCC)=O)([2H])C([2H])([2H])OC(CCCCCCC/C=C\CCCCCCCC)=O | ||
| Formula | C57H99D5O6 | M.Wt | 890.5 |
| الذوبان | Chloroform: Slightly soluble: 0.1-1 mg/ml,Ethanol: Soluble: ≥10 mg/ml,Methanol: Slightly soluble: 0.1-1 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.123 mL | 5.6148 mL | 11.2296 mL |
| 5 mM | 0.2246 mL | 1.123 mL | 2.2459 mL |
| 10 mM | 0.1123 mL | 0.5615 mL | 1.123 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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