1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt) (Synonyms: biotin-cap-DPPE) |
رقم الكتالوجGC41823 |
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 384835-52-3
Sample solution is provided at 25 µL, 10mM.
1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid. It has been used in PEGylated polyamidoamine-dendrimer-conjugated supported lipid bilayers (SLB) to isolate circulating tumor cells and tumor cell microembolis from patient-derived blood by antibody-coated microfluidics. [1] It has also been used as a component of SLBs to detect protein-ligand binding with ortho-conjugated Texas Red DHPE. [2] In addition, 1,2-dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) has been used in SLBs partitioned into nanowells to create DNA curtains, which can be used as a high-throughput tool for detection of protein-DNA interactions at the single molecule level.[3]
Reference:
[1]. Yeh, P.-Y., Chen, Y.-R., Wang, C.-F., et al. Promoting multivalent antibody-antigen interactions by tethering antibody molecules on a PEGylated dendrimer-supported lipid bilayer. Biomolecules 19(2), 426-437 (2018).
[2]. Jung, H., Robison, A.D., and Cremer, P.S. Detecting protein-ligand binding on supported bilayers by local pH modulation. J. Am. Chem. Soc. 131(3), 1006-1014 (2009).
[3]. Visnapuu, M.-L., Fazio, T., Wind, S., et al. Parallel arrays of geometric nanowells for assembling curtains of DNA with controlled lateral dispersion. Langmuir 24(19), 11293-11299 (2008).
Cas No. | 384835-52-3 | SDF | |
المرادفات | biotin-cap-DPPE | ||
Chemical Name | hexadecanoic acid, 1,1'-[(1R)-1-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-3-hydroxy-3-oxido-8,15-dioxo-2,4-dioxa-7,14-diaza-3-phosphanonadec-1-yl]-1,2-ethanediyl] ester, monosodium salt | ||
Canonical SMILES | O=C(CCCCCCCCCCCCCCC)OC[C@@H](OC(CCCCCCCCCCCCCCC)=O)COP(OCCNC(CCCCCNC(CCCC[C@H]1[C@](NC(N2)=O)([H])[C@]2([H])CS1)=O)=O)([O-])=O.[Na+] | ||
Formula | C53H98N4O11PS•Na | M.Wt | 1053.4 |
الذوبان | Slightly soluble in DMSO | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
1 mM | 0.9493 mL | 4.7465 mL | 9.4931 mL |
5 mM | 0.1899 mL | 0.9493 mL | 1.8986 mL |
10 mM | 0.0949 mL | 0.4747 mL | 0.9493 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5
(Based on Reviews and 6 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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