الصفحة الرئيسية>>Lipids>> Glycerophospholipids>>1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt)

1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt) (Synonyms: biotin-cap-DPPE)

رقم الكتالوجGC41823

1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid.

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1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt) التركيب الكيميائي

Cas No.: 384835-52-3

الحجم السعر المخزون الكميّة
5mg
60٫00
متوفر
10mg
108٫00
متوفر
25mg
240٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of 1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt)

1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) is a biotinylated phospholipid. It has been used in PEGylated polyamidoamine-dendrimer-conjugated supported lipid bilayers (SLB) to isolate circulating tumor cells and tumor cell microembolis from patient-derived blood by antibody-coated microfluidics. [1]  It has also been used as a component of SLBs to detect protein-ligand binding with ortho-conjugated Texas Red DHPE. [2] In addition, 1,2-dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) has been used in SLBs partitioned into nanowells to create DNA curtains, which can be used as a high-throughput tool for detection of protein-DNA interactions at the single molecule level.[3]

Reference:
[1]. Yeh, P.-Y., Chen, Y.-R., Wang, C.-F., et al. Promoting multivalent antibody-antigen interactions by tethering antibody molecules on a PEGylated dendrimer-supported lipid bilayer. Biomolecules 19(2), 426-437 (2018).
[2]. Jung, H., Robison, A.D., and Cremer, P.S. Detecting protein-ligand binding on supported bilayers by local pH modulation. J. Am. Chem. Soc. 131(3), 1006-1014 (2009).
[3]. Visnapuu, M.-L., Fazio, T., Wind, S., et al. Parallel arrays of geometric nanowells for assembling curtains of DNA with controlled lateral dispersion. Langmuir 24(19), 11293-11299 (2008).

Chemical Properties of 1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt)

Cas No. 384835-52-3 SDF
المرادفات biotin-cap-DPPE
Chemical Name hexadecanoic acid, 1,1'-[(1R)-1-[19-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-3-hydroxy-3-oxido-8,15-dioxo-2,4-dioxa-7,14-diaza-3-phosphanonadec-1-yl]-1,2-ethanediyl] ester, monosodium salt
Canonical SMILES O=C(CCCCCCCCCCCCCCC)OC[C@@H](OC(CCCCCCCCCCCCCCC)=O)COP(OCCNC(CCCCCNC(CCCC[C@H]1[C@](NC(N2)=O)([H])[C@]2([H])CS1)=O)=O)([O-])=O.[Na+]
Formula C53H98N4O11PS•Na M.Wt 1053.4
الذوبان Slightly soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt)

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 0.9493 mL 4.7465 mL 9.4931 mL
5 mM 0.1899 mL 0.9493 mL 1.8986 mL
10 mM 0.0949 mL 0.4747 mL 0.9493 mL
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In vivo Formulation Calculator (Clear solution) of 1,2-Dipalmitoyl-sn-glycero-3-PE-N-(cap biotin) (sodium salt)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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