الصفحة الرئيسية>>Signaling Pathways>> TGF-β / Smad Signaling>> SMAD>>10,11-dehydro Curvularin

10,11-dehydro Curvularin (Synonyms: α,β-dehydro Curvularin)

رقم الكتالوجGC41863

10،11-ديهيدرو Curvularin هو سمن نباتي فطري سائد ومضاد حيوي.

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10,11-dehydro Curvularin التركيب الكيميائي

Cas No.: 21178-57-4

الحجم السعر المخزون الكميّة
1mg
113٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of 10,11-dehydro Curvularin

10,11-Dehydrocurvularin is an antibiotic and a strong activator of the heat shock response, a conserved evolutionary mechanism that maintains protein homeostasis via the overexpression of heat shock factor 1 (HSF1) and various chaperones including heat shock protein 90 (Hsp90). 10,11-Dehydrocurvularin inhibits TGF-β signalling pathway. Anti-tumorous activity[1][2].

References:
[1]. Xu Y, et al. Characterization of the biosynthetic genes for 10,11-dehydrocurvularin, a heat shock response-modulating anticancer fungal polyketide from Aspergillus terreus. Appl Environ Microbiol. 2013 Mar;79(6):2038-47.
[2]. Cochrane RV, et al. Comparison of 10,11-Dehydrocurvularin Polyketide Synthases from Alternaria cinerariae and Aspergillus terreus Highlights Key Structural Motifs. Chembiochem. 2015 Nov;16(17):2479-83.

Chemical Properties of 10,11-dehydro Curvularin

Cas No. 21178-57-4 SDF
المرادفات α,β-dehydro Curvularin
Chemical Name (4S,8E)-4,5,6,7-tetrahydro-11,13-dihydroxy-4-methyl-2H-3-benzoxacyclododecin-2,10(1H)-dione
Canonical SMILES O=C1CC2=C(C(/C=C/CCC[C@H](C)O1)=O)C(O)=CC(O)=C2
Formula C16H18O5 M.Wt 290.3
الذوبان 30mg/mL in DMSO, 30mg/mL in DMF, 10mg/mL in Ethanol Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 10,11-dehydro Curvularin

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1 mg 5 mg 10 mg
1 mM 3.4447 mL 17.2236 mL 34.4471 mL
5 mM 0.6889 mL 3.4447 mL 6.8894 mL
10 mM 0.3445 mL 1.7224 mL 3.4447 mL
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In vivo Formulation Calculator (Clear solution) of 10,11-dehydro Curvularin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
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3. All of the above co-solvents are available for purchase on the GlpBio website.

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Review for 10,11-dehydro Curvularin

Average Rating: 5 ★★★★★ (Based on Reviews and 12 reference(s) in Google Scholar.)

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