الصفحة الرئيسية>>Signaling Pathways>> Cell Cycle/Checkpoint>> Microtubule/Tubulin>>10-acetyl Docetaxel

10-acetyl Docetaxel (Synonyms: PNU 101383, 10-acetyl Taxotere)

رقم الكتالوجGC49736

10-أسيتيل دوسيتاكسيل (10-أسيتيل دوسيتاكسيل) هو نظير لدوسيتاكسيل ، مع نشاط مضاد للسرطان. Docetaxel هو مثبط لتفكيك الأنابيب الدقيقة ، مع نشاط مضاد.

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10-acetyl Docetaxel التركيب الكيميائي

Cas No.: 125354-16-7

الحجم السعر المخزون الكميّة
50mg
93٫00
متوفر
100mg
155٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of 10-acetyl Docetaxel

10-acetyl Docetaxel is a derivative of paclitaxel and an inhibitor of microtubule depolymerization.1 It inhibits calcium-induced depolymerization of calf brain microtubule protein (MTP) in a cell-free assay when used at 20 µM. 10-acetyl Docetaxel is cytotoxic to J774.2 cells (EC50 = 0.05 µM).

1.Swindell, C.S., Heerding, J.M., Krauss, N.E., et al.Characterization of the taxol structure-activity profile for the locus of the A-ring side chainBioorg. Med. Chem. Lett.4(12)1531-1536(1994)

Chemical Properties of 10-acetyl Docetaxel

Cas No. 125354-16-7 SDF
المرادفات PNU 101383, 10-acetyl Taxotere
Canonical SMILES C[C@]1(C([C@@H](C2=C(C)[C@@H](OC([C@H](O)[C@@H](NC(OC(C)(C)C)=O)C3=CC=CC=C3)=O)C[C@]4(O)C2(C)C)OC(C)=O)=O)[C@@]([C@@H]4OC(C5=CC=CC=C5)=O)([H])[C@@]([C@@]6([H])C[C@@H]1O)(CO6)OC(C)=O
Formula C45H55NO15 M.Wt 849.9
الذوبان DMF: 2 mg/ml,DMSO: 3 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): insol Storage -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 10-acetyl Docetaxel

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.1766 mL 5.883 mL 11.7661 mL
5 mM 0.2353 mL 1.1766 mL 2.3532 mL
10 mM 0.1177 mL 0.5883 mL 1.1766 mL
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In vivo Formulation Calculator (Clear solution) of 10-acetyl Docetaxel

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 1 reference(s) in Google Scholar.)

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