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10074-A4

رقم الكتالوجGC63576

10074-A4 هو مثبط c-Mycيمكن أن يرتبط 10074-A4 بـ c-Myc370-409 في مواقع مختلفة على طول سلسلة الببتيد10074-A4 له تأثيرات مضادة للسرطان

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10074-A4 التركيب الكيميائي

Cas No.: 312631-87-1

الحجم السعر المخزون الكميّة
5 mg
252٫00
متوفر
10 mg
378٫00
متوفر
25 mg
576٫00
متوفر
50 mg
864٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of 10074-A4

10074-A4 is a c-Myc inhibitor. 10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain. 10074-A4 has anticancer effects[1][2].

10074-A4 shows inhibitory activity of HL-60 cells with an IC50 of 15.1 μM[1].10074-A4 (25-50 μM; 24 hours) arrests the cell cycle at the S-phase in a dose-dependent manner in HL-60 cells. 10074-A4 inhibits the mRNA level of the c-Myc target genes, CCND2 and CDK4[1].10074-A4 could bind to c-Myc370-409 at different sites along the peptide chain and its binding behavior could be described as a ’ligand cloud’. Even in the bound state, the structure of the c-Myc370-409 peptide remained a dynamic ensemble. The 10074-A4 ligand bound at different sites throughout the c-Myc370-409 chain with different strength[2].

[1]. Chen Yu, et al. Structure-based Inhibitor Design for the Intrinsically Disordered Protein c-Myc. Sci Rep. 2016 Mar 2;6:22298.
[2]. Fan Jin, et al. Ligand clouds around protein clouds: a scenario of ligand binding with intrinsically disordered proteins. PLoS Comput Biol. 2013;9(10):e1003249.

Chemical Properties of 10074-A4

Cas No. 312631-87-1 SDF
Formula C18H14Cl2N2O3S M.Wt 409.29
الذوبان Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 10074-A4

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.4433 mL 12.2163 mL 24.4326 mL
5 mM 0.4887 mL 2.4433 mL 4.8865 mL
10 mM 0.2443 mL 1.2216 mL 2.4433 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 12 reference(s) in Google Scholar.)

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