الصفحة الرئيسية>>Lipids>> Prostaglandins>>15-deoxy-δ12,14-Prostaglandin J2-2-glyceryl ester

15-deoxy-δ12,14-Prostaglandin J2-2-glyceryl ester (Synonyms: 15-deoxy-δ12,14-PGJ2-2-glyceryl ester)

رقم الكتالوجGC91402

يتم تشكيل استر 15-ديوكسي -δ12،14-بروستاجلاندين ج2-2-غليسيريل (15-deoxy-δ12,14-PGJ2-2-glyceryl ester) من PGD2 عن طريق إزالة جزيئات الماء اثنتان.

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15-deoxy-δ12,14-Prostaglandin J2-2-glyceryl ester التركيب الكيميائي

الحجم السعر المخزون الكميّة
100μg
69٫00
متوفر
500μg
302٫00
متوفر
1mg
532٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of 15-deoxy-δ12,14-Prostaglandin J2-2-glyceryl ester

15-deoxy-δ12,14-Prostaglandin J2-2-glyceryl ester (15-deoxy-δ12,14-PGJ2-2-glyceryl ester) is formed from PGD2 by the elimination of two molecules of water. It binds selectively to PPARγ with an EC50 value of 2 µM in a murine chimera system.1,2 15-deoxy-δ12,14-PGJ2-2-glyceryl ester is more potent than PGD2, δ12-PGJ2, and PGJ2 in stimulating lipogenesis in C3H10T1/2 cells. The EC50 value for induction of adipocyte differentiation in cultured fibroblasts is 7 µM.1 PG glycerol esters are generated by the action of cyclooxygenase-2 on the endocannabinoid 2-arachidonyl glycerol.3 The biosynthesis of PGH, PGD, PGE, PGF, and TXA-2-glyceryl ester compounds have all been documented. While the stability and metabolism of these PG products has been investigated,4 little is known about their intrinsic biological activity.

Chemical Properties of 15-deoxy-δ12,14-Prostaglandin J2-2-glyceryl ester

Cas No. SDF
المرادفات 15-deoxy-δ12,14-PGJ2-2-glyceryl ester
Formula C23H34O5 M.Wt 390.5
الذوبان DMF: 25 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 0.3 mg/ml Storage Store at -80°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 15-deoxy-δ12,14-Prostaglandin J2-2-glyceryl ester

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.5608 mL 12.8041 mL 25.6082 mL
5 mM 0.5122 mL 2.5608 mL 5.1216 mL
10 mM 0.2561 mL 1.2804 mL 2.5608 mL
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In vivo Formulation Calculator (Clear solution) of 15-deoxy-δ12,14-Prostaglandin J2-2-glyceryl ester

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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