الصفحة الرئيسية>>Lipids>> Prostaglandins>>15-deoxy-δ12,14-Prostaglandin J2-biotin

15-deoxy-δ12,14-Prostaglandin J2-biotin (Synonyms: 15deoxyΔ12,14PGJ2biotin)

رقم الكتالوجGC46446

A neuropeptide with diverse biological activities

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15-deoxy-δ12,14-Prostaglandin J2-biotin التركيب الكيميائي

Cas No.: N/A

الحجم السعر المخزون الكميّة
50 μg
180٫00
متوفر
100 μg
342٫00
متوفر
500 μg
1439٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of 15-deoxy-δ12,14-Prostaglandin J2-biotin

15-deoxy-δ12,14-Prostaglandin J2 is one of the cyclopentenone PGs, which have documented metabolic (peroxisome proliferator-activated receptor γ-activating), antimitotic, and antiproliferative effects.1,2,3 The activity of the compounds in this class, which includes PGs in both the A- and J-series, may result from changes in gene expression and the interaction with non-classical (i.e., non-G protein-coupled receptor) pathways. 15-deoxy-δ12,14-PGJ2-biotin is an affinity probe which allows 15-deoxy-δ12,14-PGJ2 to be detected through an interaction with the biotin ligand. 15-deoxy-δ12,14-PGJ2-biotin was designed to allow 15-deoxy-δ12,14-PGJ2 to be detected in complexes with nuclear receptors and/or nucleic acid or protein binding partners. It is thus a tool to be used in the general elucidation of the mechanism of action of the cyclopentenone PGs.

1.Krakoff, L.R., Vlachakis, N., Mendlowitz, M., et al.Differential effect of prostaglandin A1 in hypertensive patients with low, normal and high reninClinical Science and Molecular Medicine48311s-313s(1975) 2.Kikuchi, Y., Kita, T., Hirata, J., et al.Preclinical studies of antitumor prostaglandins by using human ovarian cancer cellsCancer Metastasis Rev.13(3-4)309-315(1994) 3.Mueller, E., Drori, S., Aiyer, A., et al.Genetic analysis of adipogenesis through peroxisome proliferator-activated receptor γ isoformsThe Journal of Biological Chemisty277(44)41925-41930(2002)

Chemical Properties of 15-deoxy-δ12,14-Prostaglandin J2-biotin

Cas No. N/A SDF
المرادفات 15deoxyΔ12,14PGJ2biotin
Canonical SMILES O=C1C=C[C@H](C/C=C\CCCC(NCCCCCNC(CCCC[C@@H]2[C@]3([H])[C@](NC(N3)=O)([H])CS2)=O)=O)/C1=C\C=C\CCCCC
Formula C35H54N4O4S M.Wt 626.9
الذوبان DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml,PBS (pH 7.2): 1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 15-deoxy-δ12,14-Prostaglandin J2-biotin

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.5952 mL 7.9758 mL 15.9515 mL
5 mM 0.319 mL 1.5952 mL 3.1903 mL
10 mM 0.1595 mL 0.7976 mL 1.5952 mL
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In vivo Formulation Calculator (Clear solution) of 15-deoxy-δ12,14-Prostaglandin J2-biotin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 15 reference(s) in Google Scholar.)

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