الصفحة الرئيسية>>Signaling Pathways>> GPCR/G protein>> P2Y Receptor>>(±)-Clopidogrel (hydrochloride)

(±)-Clopidogrel (hydrochloride)

رقم الكتالوجGC41668

Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM).

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(±)-Clopidogrel (hydrochloride) التركيب الكيميائي

Cas No.: 130209-90-4

الحجم السعر المخزون الكميّة
10mg
192٫00
متوفر
50mg
857٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of (±)-Clopidogrel (hydrochloride)

Clopidogrel is an antithrombic compound whose active metabolite is a selective, irreversible antagonist of the platelet purinergic P2Y12 receptor (IC50 = 100 nM). Clopidogrel inhibits ADP-induced platelet aggregation ex vivo and functions as a prodrug whereupon biotransformation to its active metabolite via CYP2C19 in the liver enables its anti-aggregating activity. Marketed under the name Plavix®, clopidogrel in combination with aspirin has been shown to be beneficial in the prevention of vascular ischemic events for patients without deficiencies in CYP2C19-related metabolism.

Chemical Properties of (±)-Clopidogrel (hydrochloride)

Cas No. 130209-90-4 SDF
Canonical SMILES ClC1=CC=CC=C1C(C(OC)=O)N2CCC(SC=C3)=C3C2.Cl
Formula C16H16ClNO2S•HCl M.Wt 358.3
الذوبان DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS(pH 7.2) (1:2): 0.33 mg/ml,Ethanol: 5 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (±)-Clopidogrel (hydrochloride)

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.791 mL 13.9548 mL 27.9096 mL
5 mM 0.5582 mL 2.791 mL 5.5819 mL
10 mM 0.2791 mL 1.3955 mL 2.791 mL
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In vivo Formulation Calculator (Clear solution) of (±)-Clopidogrel (hydrochloride)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 12 reference(s) in Google Scholar.)

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