الصفحة الرئيسية>>Signaling Pathways>> GPCR/G protein>> Prostaglandin Receptor>>(±)-Cloprostenol sodium salt

(±)-Cloprostenol sodium salt (Synonyms: (±)16mchlorophenoxy tetranor PGF2α, (±)16mchlorophenoxy tetranor Prostaglandin F2α, DLCloprostenol)

رقم الكتالوجGC16838

(± ؛) - ملح الصوديوم كلوبروستينول (ملح الصوديوم ICI 80996) هو نظير بروستاغلاندين اصطناعي قوي ، يعمل كعامل محلل أصفري ، وهو ناهض لمستقبلات PGF2α.

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(±)-Cloprostenol sodium salt التركيب الكيميائي

Cas No.: 55028-72-3

الحجم السعر المخزون الكميّة
5mg
113٫00
متوفر
10mM (in 1mL Water)
124٫00
متوفر
10mg
176٫00
متوفر
25mg
356٫00
متوفر
50mg
509٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of (±)-Cloprostenol sodium salt

Cloprostenol sodium salt (ICI 80996 sodium salt) is a potent synthetic prostaglandin analogue, acts as a luteolytic agent[1], and is a PGF2α receptor agonist[2].

Cloprostenol is a PGF2α receptor agonist[2].Cloprostenol (0.1 μM) counteracts the adipogenic effects of statil, on both intracellular lipid accumulation and expression of transcripts for proadipogenic factors C/EBPα and PPARγ after treatment for 6 days[2].

Cloprostenol sodium salt (25 μg) decreases plasma progesterone in pregnant rats[1].

References:
[1]. Salazar H, et al. Luteolytic effects of a prostaglandin analogue, cloprostenol (ICI 80,996), in rats: ultrastructural and biochemical observations. Biol Reprod. 1976 May;14(4):458-72.
[2]. Pastel E, et al. Aldose reductases influence prostaglandin F2α levels and adipocyte differentiation in male mouse and human species. Endocrinology. 2015 May;156(5):1671-84.

Chemical Properties of (±)-Cloprostenol sodium salt

Cas No. 55028-72-3 SDF
المرادفات (±)16mchlorophenoxy tetranor PGF2α, (±)16mchlorophenoxy tetranor Prostaglandin F2α, DLCloprostenol
Chemical Name sodium (E)-7-((1R,2R,3S,5R)-2-((R,Z)-4-(3-chlorophenoxy)-3-hydroxybut-1-en-1-yl)-3,5-dihydroxycyclopentyl)hept-5-enoate
Canonical SMILES ClC1=CC(OC[C@@H](/C=C\[C@@H]([C@H]2O)[C@@H](C/C=C/CCCC([O-])=O)[C@@H](C2)O)O)=CC=C1.[Na+]
Formula C22H28ClNaO6 M.Wt 446.9
الذوبان DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml Storage Desiccate at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (±)-Cloprostenol sodium salt

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.2376 mL 11.1882 mL 22.3764 mL
5 mM 0.4475 mL 2.2376 mL 4.4753 mL
10 mM 0.2238 mL 1.1188 mL 2.2376 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
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