الصفحة الرئيسية>>Isotope-Labeled Compounds>> Deuterium>>(±)-Sitagliptin-d4 (hydrochloride)

(±)-Sitagliptin-d4 (hydrochloride)

رقم الكتالوجGC46308

A neuropeptide with diverse biological activities

Products are for research use only. Not for human use. We do not sell to patients.

(±)-Sitagliptin-d4 (hydrochloride) التركيب الكيميائي

Cas No.: 2749855-96-5

الحجم السعر المخزون الكميّة
500 μg
255٫00
متوفر
1 mg
485٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com


مراجعات العميل

بناء على آراء العملاء.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Description of (±)-Sitagliptin-d4 (hydrochloride)

(±)-Sitagliptin-d4 is intended for use as an internal standard for the quantification of sitagliptin by GC- or LC-MS. Sitagliptin is a mixture of the dipeptidyl peptidase 4 (DPP-4) inhibitor (-)-sitagliptin and (+)-sitagliptin, also known as sitagliptin impurity E, a potential impurity found in commercial preparations of (-)-sitagliptin.1 (-)-Sitagliptin is a potent inhibitor of DPP-4 (IC50 = 18 nM).2 It is selective for DPP-4 over DPP-8 (IC50 = 48 µM) as well as several other peptidases, including DPP-9, DPP-2, and amino peptidase P.2,3 (-)-Sitagliptin improves glucose tolerance in insulin-resistant Zucker fatty and high-fat diet fed rats as well as ob/ob and high-fat diet fed mice.4 It also reduces hyperglycemia in mice fed a high-fat diet with diabetes induced by streptozotocin . Formulations containing (-)-sitagliptin have been used in the treatment of type 2 diabetes mellitus.

1.Kothari, H.M., Dave, M.G., Pandey, B., et al.Process for preparation of (2R)-4-oxo-4-[3-(trifluoromethyl)-5,6-dihydro [1,2,4]-triazolo[4,3-α]pyrazin-7(8H)-yl]-L-(2,4,5-trifluorophenyl)butan-2-amine and new impurities in preparation thereof(2013) 2.Biftu, T., Feng, D., Qian, X., et al.(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoroethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetesBioorg. Med. Chem. Lett.17(1)49-52(2007) 3.Kim, D., Kowalchick, J.E., Edmondson, S.D., et al.Triazolopiperazine-amides as dipeptidyl peptidase IV inhibitors: Close analogs of JANUVIAT (sitagliptin phosphate)Bioorg. Med. Chem. Lett.17(12)3373-3377(2007) 4.AhrÉn, B.DPP-4 inhibitorsBest Pract.Res.Clin.Endocrinol.Metab.21(4)517-533(2007)

Chemical Properties of (±)-Sitagliptin-d4 (hydrochloride)

Cas No. 2749855-96-5 SDF
Canonical SMILES FC1=CC(CC(N)CC(N2CC3=NN=C(C(F)(F)F)N3C([2H])([2H])C2([2H])[2H])=O)=C(F)C=C1F.Cl
Formula C16H11D4F6N5O.HCl M.Wt 447.8
الذوبان Water: Soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (±)-Sitagliptin-d4 (hydrochloride)

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.2331 mL 11.1657 mL 22.3314 mL
5 mM 0.4466 mL 2.2331 mL 4.4663 mL
10 mM 0.2233 mL 1.1166 mL 2.2331 mL
  • حاسبة المولارية

  • حاسبة التخفيف

  • Molecular Weight Calculator

كتلة
=
تركيز
x
مقدار
x
ميغاواط *
 
 
 
** عند إعداد حلول المخزون، دائمًا استخدم الوزن الجزيئي الخاص بالدفعة للمنتج على ملصق القارورة MSDS / CoA (متوفر عبر الإنترنت).

احسب

In vivo Formulation Calculator (Clear solution) of (±)-Sitagliptin-d4 (hydrochloride)

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

View current batch:

مراجعات

Review for (±)-Sitagliptin-d4 (hydrochloride)

Average Rating: 5 ★★★★★ (Based on Reviews and 22 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for (±)-Sitagliptin-d4 (hydrochloride)

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.