2-chloro Palmitic Acid (Synonyms: 2-ClHA, 2-CLPA) |
| رقم الكتالوجGC42135 |
2-chloro Palmitic Acid ، وهو وسيط شحمي التهابي ، يتداخل مع بروتين نخيل البروتين ، ويحفز علامات الإجهاد ER ، ويقلل من محتوى ER ATP ، وينشط نسخ وإفراز IL-6 وكذلك IL-8.2-chloro Palmitic Acid يعطل الميتوكوندريا إمكانات الغشاء ويحفز انشقاق procaspase-3 و PARP. 2-chloro Palmitic Acid يمكن أن يعبر حاجز الدم في الدماغ (BBB) ويقوض وظائف ER والميتوكوندريا في خط الخلايا البطانية للدماغ البشري hCMEC / D3.
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Cas No.: 19117-92-1
Sample solution is provided at 25 µL, 10mM.
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2-chloro Palmitic acid is a monochlorinated form of palmitic acid . It is produced in a myeloperoxidase (MPO) and time-dependent manner in neutrophils stimulated by phorbol 12-myristate 13-acetate . 2-chloro Palmitic acid (10 μM) induces neutrophil extracellular trap (NET) formation (NETosis) in human neutrophils, increasing DNA release from neutrophils, colocalization of MPO with extracellular DNA (ecDNA), and trapping of E. coli. It increases COX-2 protein levels in human coronary artery endothelial cells (HCAECs) when used at a concentration of 50 μM and increases production of P-selectin, von Willebrand factor, and angiopoietin-2 in HCAECs, as well as neutrophil and platelet adherence, when used at a concentration of 10 μM. 2-chloro Palmitic acid (10-50 μM) also induces apoptosis in THP-1 cells and primary human monocytes and increases caspase-3 activity in THP-1 cells.
| Cas No. | 19117-92-1 | SDF | |
| المرادفات | 2-ClHA, 2-CLPA | ||
| Canonical SMILES | CCCCCCCCCCCCCCC(Cl)C(O)=O | ||
| Formula | C16H31ClO2 | M.Wt | 290.9 |
| الذوبان | DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 30 mg/ml,Ethanol:PBS (pH 7.2) (1:3): 0.25 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.4376 mL | 17.188 mL | 34.3761 mL |
| 5 mM | 0.6875 mL | 3.4376 mL | 6.8752 mL |
| 10 mM | 0.3438 mL | 1.7188 mL | 3.4376 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 6 reference(s) in Google Scholar.)
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