4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline (Synonyms: 4-Aminophenylboronic Acid pinacol ester) |
| رقم الكتالوجGC46606 |
A heterocyclic building block
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 214360-73-3
Sample solution is provided at 25 µL, 10mM.
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4-(4,4,5,5-Tetramethyl-1,3,2-dioxaboran-2yl)aniline is a heterocyclic building block.1,2 It has been used in the synthesis of 3-aminoindazole-based multi-targeted receptor tyrosine kinase (RTK) inhibitors with anticancer activity and roscovitine derivatives that are dual inhibitors of cyclin-dependent kinases (CDKs) and casein kinase 1 (CK1).
1.Dai, Y., Hartandi, K., Ji, Z., et al.Discovery of N-(4-(3-amino-1H-indazol-4-yl)phenyl)-N'-(2-fluoro-5-methylphenyl)urea (ABT-869), a 3-aminoindazole-based orally active multitargeted receptor tyrosine kinase inhibitorJ. Med. Chem.50(7)1584-1597(2007) 2.Paraiso, K.H.T., Haarberg, H.E., Wood, E., et al.The HSP90 inhibitor XL888 overcomes BRAF inhibitor resistance mediated through diverse mechanismsClin. Cancer Res.18(9)2502-2514(2012)
| Cas No. | 214360-73-3 | SDF | |
| المرادفات | 4-Aminophenylboronic Acid pinacol ester | ||
| Canonical SMILES | NC(C=C1)=CC=C1B2OC(C)(C)C(C)(C)O2 | ||
| Formula | C12H18BNO2 | M.Wt | 219.1 |
| الذوبان | DMF: 20mg/mL,DMF:PBS (pH 7.2) (1:5): 0.16mg/mL,DMSO: 10mg/mL,Ethanol: 3mg/mL | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.5641 mL | 22.8206 mL | 45.6413 mL |
| 5 mM | 0.9128 mL | 4.5641 mL | 9.1283 mL |
| 10 mM | 0.4564 mL | 2.2821 mL | 4.5641 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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