الصفحة الرئيسية>>Signaling Pathways>> Neuroscience>> 5-HT Receptor>>(4E)-SUN9221

(4E)-SUN9221

رقم الكتالوجGC32644

(4E) -SUN9221 هو مضاد قوي لمستقبلات α1 الأدرينالية ومستقبلات 5-HT2 ، مع أنشطة التجميع الخافضة للضغط والصفائح الدموية

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(4E)-SUN9221 التركيب الكيميائي

Cas No.: 222318-55-0

الحجم السعر المخزون الكميّة
1mg
1324٫00
متوفر
5mg
2979٫00
متوفر
10mg
5066٫00
متوفر
20mg
8935٫00
متوفر

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مراجعات العميل

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  • GlpBio Citations

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Sample solution is provided at 25 µL, 10mM.

Description of (4E)-SUN9221

(4E)-SUN9221 is a potent antagonist of α1-adrenergic receptor and 5-HT2 receptor, with antihypertensive and anti-platelet aggregation activities.

(4E)-SUN9221 potently inhibits collagen-, ADP- and epinephrine-induced platelet aggregation, with IC50s of 10 nM, 35 nM, 14 nM, respectively, in human platelet-rich plasma (PRP). (4E)-SUN9221 displays potent α1-adrenergic antagonist activity (pA2 =8.89±0.21) and 5-HT2 antagonist activity (pA2 =8.74±0.22)[1].

(4E)-SUN9221 (1, 3, 10 mg/kg, p.o.) reduces the blood pressure in a dose-dependent manner in conscious spontaneously hypertensive rats (SHR). (4E)-SUN9221 (3 mg/kg) exhibits antihypertensive activity in SHR[1].

[1]. Mizuno A, et al. Synthesis and pharmacological evaluation of pyrroloazepine derivatives as potent antihypertensive agents with antiplatelet aggregation activity. Chem Pharm Bull (Tokyo). 1999 Feb;47(2):246-56.

Chemical Properties of (4E)-SUN9221

Cas No. 222318-55-0 SDF
Canonical SMILES O=C(C1=C/2C=CN1CCCCN3CCC(C(C4=CC=C(F)C=C4)=O)CC3)N(C)CCC2=N/O
Formula C25H31FN4O3 M.Wt 454.54
الذوبان Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (4E)-SUN9221

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.2 mL 11.0001 mL 22.0003 mL
5 mM 0.44 mL 2.2 mL 4.4001 mL
10 mM 0.22 mL 1.1 mL 2.2 mL
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Average Rating: 5 ★★★★★ (Based on Reviews and 39 reference(s) in Google Scholar.)

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