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(4S)-PROTAC SOS1 degrader-1 diTFA

رقم الكتالوجGC73101

(4S)-PROTAC SOS1 degrader-1 diTFA هو محلل قوي PROTAC SOS1.

Products are for research use only. Not for human use. We do not sell to patients.

(4S)-PROTAC SOS1 degrader-1 diTFA التركيب الكيميائي

الحجم السعر المخزون الكميّة
1 mg
432٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com


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Sample solution is provided at 25 µL, 10mM.

Description of (4S)-PROTAC SOS1 degrader-1 diTFA

(4S)-PROTAC SOS1 degrader-1 (diTFA) is a potent PROTAC SOS1 degrader. (4S)-PROTAC SOS1 degrader-1 (diTFA) decreases the expression of pERK and RAS-GTP level in a dose-dependent manner. (4S)-PROTAC SOS1 degrader-1 (diTFA) significantly inhibits the tumor growth in vivo.

References:
[1]. Zhou C,et al. Discovery of the First-in-Class Agonist-Based SOS1 PROTACs Effective in Human Cancer Cells Harboring Various KRAS Mutations. J Med Chem. 2022; 65(5):3923-3942.

Chemical Properties of (4S)-PROTAC SOS1 degrader-1 diTFA

Cas No. SDF
Formula C61H78ClF7N10O8S M.Wt 1279.84
الذوبان DMSO : 100 mg/mL (78.13 mM; Need ultrasonic) Storage -20°C, sealed storage, away from moisture and light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (4S)-PROTAC SOS1 degrader-1 diTFA

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 0.7813 mL 3.9067 mL 7.8135 mL
5 mM 0.1563 mL 0.7813 mL 1.5627 mL
10 mM 0.0781 mL 0.3907 mL 0.7813 mL
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In vivo Formulation Calculator (Clear solution) of (4S)-PROTAC SOS1 degrader-1 diTFA

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

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Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

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Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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