الصفحة الرئيسية>>Signaling Pathways>> GPCR/G protein>> 5-HT Receptor>>(-)-5-HT2C agonist-3

(-)-5-HT2C agonist-3

رقم الكتالوجGC73658

مركب (-)-5-HT2C agonist-3 --19 هو ناقد انتقائي 5-HT2C مع تفضيل إشارات Gq، مع قيم EC50 لمستقبلات 5-HT2 من 5-HT2C: 103 نانومتر ؛ 5-HT2B: 570 نانومتر ؛ 5-HT2A: 72 نانومتر.

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(-)-5-HT2C agonist-3 التركيب الكيميائي

Cas No.: 2104810-16-2

الحجم السعر المخزون الكميّة
1 mg
180٫00
متوفر
5 mg
450٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of (-)-5-HT2C agonist-3

(-)-5-HT2C agonist-3 (compound (–)-19) is a 5-HT2C selective agonist with Gq signaling preference, with EC50 values ??for 5-HT2 receptors of 5-HT2C: 103 nM; 5-HT2B: 570 nM; 5-HT2A: 72 nM. (-)-5-HT2C agonist-3 can be used in antipsychotic research[1].


References:
[1]. Guiping Zhang, et al. "Discovery of N-substituted (2-phenylcyclopropyl) metlamines as functionally selective serotonin 2C receptor agonists for potential use as antipsychotic medications." Journal of medicinal chemistry 60.14 (2017): 6273-6288.

Chemical Properties of (-)-5-HT2C agonist-3

Cas No. 2104810-16-2 SDF
Formula C19H23ClFNO2 M.Wt 351.84
الذوبان DMSO : 100 mg/mL (284.22 mM; Need ultrasonic) Storage 4°C, sealed storage, away from moisture
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of (-)-5-HT2C agonist-3

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.8422 mL 14.211 mL 28.422 mL
5 mM 0.5684 mL 2.8422 mL 5.6844 mL
10 mM 0.2842 mL 1.4211 mL 2.8422 mL
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