الصفحة الرئيسية>>Isotope-Labeled Compounds>> Deuterium>>5'-Deoxy-5'-methylthioadenosine-d3

5'-Deoxy-5'-methylthioadenosine-d3 (Synonyms: 5'-S-Methylthioadenosine-d3, MTA-d3, Vitamin L2-d3)

رقم الكتالوجGC46687

A neuropeptide with diverse biological activities

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5'-Deoxy-5'-methylthioadenosine-d3 التركيب الكيميائي

Cas No.: 174838-38-1

الحجم السعر المخزون الكميّة
1 mg
77٫00
متوفر
5 mg
367٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of 5'-Deoxy-5'-methylthioadenosine-d3

5'-Deoxy-5'-methylthioadenosine-d3 (MTA-d3) is intended for use as an internal standard for the quantification of MTA by GC- or LC-MS. MTA is an intermediate in the generation of adenine and methionine that is produced by the decarboxylation of S-adenosylmethionine.1 This nucleoside is a potent agonist of adenosine receptors (Kis = 0.15, 1.13, 13.9, and 0.68 μM for A1, A2A, A2B, and A3, respectively).2 At higher concentrations, MTA inhibits several enzymes, including protein carboxylmethyltransferase (Ki = 41 μM), S-adenosylhomocysteine hydrolase, SET methyltransferases, and spermidine and spermine synthases.3,1,4,5

1.Huang, S.Histone methyltransferases, diet nutrients and tumour suppressorsNat. Rev. Cancer2(6)469-476(2002) 2.Kehraus, S., Gorzalka, S., Hallmen, C., et al.Novel amino acid derived natural products from the ascidian Atriolum robustum: Identification and pharmacological characterization of a unique adenosine derivativeJ. Med. Chem.47(9)2243-2255(2004) 3.Oliva, A., Galletti, P., Zappia, V., et al.Studies on substrate specificity of S-adenosylmethionine: Protein-carboxyl methyltransferase from calf brainEur. J. Biochem.104(2)595-602(1980) 4.Cole, P.A.Chemical probes for histone-modifying enzymesNat. Chem. Biol.4(10)590-597(2008) 5.Lee, S.H., and Cho, Y.D.Induction of apoptosis in leukemia U937 cells by 5'-deoxy-5'-methylthioadenosine, a potent inhibitor of protein carboxylmethyltransferaseExp. Cell Res.240(2)282-292(1998)

Chemical Properties of 5'-Deoxy-5'-methylthioadenosine-d3

Cas No. 174838-38-1 SDF
المرادفات 5'-S-Methylthioadenosine-d3, MTA-d3, Vitamin L2-d3
Canonical SMILES O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](CSC([2H])([2H])[2H])[C@H]1O
Formula C11H12D3N5O3S M.Wt 300.3
الذوبان DMF: soluble,DMSO: slightly soluble,Methanol: slightly soluble Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 5'-Deoxy-5'-methylthioadenosine-d3

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 3.33 mL 16.65 mL 33.3 mL
5 mM 0.666 mL 3.33 mL 6.66 mL
10 mM 0.333 mL 1.665 mL 3.33 mL
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In vivo Formulation Calculator (Clear solution) of 5'-Deoxy-5'-methylthioadenosine-d3

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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