6α-Hydroxy Paclitaxel-d5 |
رقم الكتالوجGC63958 |
6α؛ -Hydroxy Paclitaxel-d5 هو الديوتيريوم المسمى 6α؛ -Hydroxy Paclitaxel. 6α ؛ -هيدروكسي باكليتاكسيل هو مستقلب أساسي للباكليتاكسيل. 6α ؛ - يحتفظ هيدروكسي باكليتاكسيل بتأثير يعتمد على الوقت على عديد ببتيدات نقل الأنيون العضوي 1B1 / SLCO1B1 (OATP1B1) مع فعالية تثبيط مماثلة لباكليتاكسيل ، في حين أنه لم يعد يظهر تثبيطًا معتمدًا على الوقت لـ OATP1B3. 6α ؛ -يمكن استخدام هيدروكسي باكليتاكسيل في أبحاث السرطان.
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Cas No.: 1315376-90-9
Sample solution is provided at 25 µL, 10mM.
6α-Hydroxy Paclitaxel-d5 is the deuterium labeled 6α-Hydroxy paclitaxel. 6α-Hydroxy paclitaxel is a primary metabolite of Paclitaxel. 6α-Hydroxy paclitaxel retains a time-dependent effect on organic anion-transporting polypeptides 1B1/SLCO1B1 (OATP1B1) with similar inhibition potency to Paclitaxel, whereas it no longer showed time-dependent inhibition of OATP1B3. 6α-Hydroxy paclitaxel can be used for the research of cancer[1].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [2]. Mori D, et al. Alteration in the Plasma Concentrations of Endogenous Organic Anion-Transporting Polypeptide 1B Biomarkers in Patients with Non-Small Cell Lung Cancer Treated with Paclitaxel. Drug Metab Dispos. 2020 May;48(5):387-394.
Cas No. | 1315376-90-9 | SDF | |
Formula | C47H46D5NO15 | M.Wt | 874.94 |
الذوبان | Storage | Store at -20°C | |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
1 mM | 1.1429 mL | 5.7147 mL | 11.4294 mL |
5 mM | 0.2286 mL | 1.1429 mL | 2.2859 mL |
10 mM | 0.1143 mL | 0.5715 mL | 1.1429 mL |
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
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Average Rating: 5
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