9(S)-HODE-13C18 (Synonyms: (+)-α-Dimorphecolic Acid) |
| رقم الكتالوجGC46755 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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9(S)-HODE-13C18 is intended for use as an internal standard for the quantification of 9(S)-HODE by GC- or LC-MS. 9(S)-HODE is a monohydroxy fatty acid formed from linoleic acid primarily by lipoxygenases with a 9-HpODE intermediate.1,2,3,4 It is an agonist of PPARγ, inducing transcription of AF-2 in a reporter assay when used at a concentration of 20 µM, and enhances the production of primary human chorionic gonadotropin (hCG) in trophoblasts.5 9(S)-HODE is also an agonist of transient receptor potential vanilloid 1 (TRPV1), TRP ankyrin 1 (TRPA1), and TRP melastatin 8 (TRPM8), increasing intracellular calcium levels in HEK293 cells (EC50s = 21, 31.9, and 43.6 µM, respectively, for the human receptors).6 It inhibits the migration of primary porcine aortic endothelial cells and phytohemagglutinin-induced migration of human mononuclear cells when used at concentrations ranging from 0.01 to 1 µM.7
1.Vick, B.A.Oxygenated fatty acids of the lipoxygenase pathwayLipid Metabolism in Plants167-191(1993) 2.Reinaud, O., Delaforge, M., Boucher, J.L., et al.Oxidative metabolism of linoleic acid by human leukocytesBiochem. Biophys. Res. Commun.161(2)883-891(1989) 3.Kim, E., Rundhaug, J.E., Benavides, F., et al.An antitumorigenic role for murine 8S-lipoxygenase in skin carcinogenesisOncogene24(7)1174-1187(2005) 4.Hamberg, M.Stereochemistry of oxygenation of linoleic acid catalyzed by prostaglandin-endoperoxide H synthase-2Arch. Biochem. Biophys.349(2)376-380(1998) 5.Schild, R.L., Schaiff, W.T., Carolson, M.G., et al.The activity of PPARγ in primary human trophoblasts is enhanced by oxidized lipidsJ. Clin. Endocrinol. Metab.87(3)1105-1110(2002) 6.De Petrocellis, L., Moriello, A.S., Imperatore, R., et al.A re-evaluation of 9-HODE activity at TRPV1 channels in comparison with anandamide: enantioselectivity and effects at other TRP channels and in sensory neuronsBr. J. Pharmacol.167(8)1643-1651(2012) 7.Pankonin, G., Mahmood, S.A., Kuhn, H., et al.Inhibition of cell migrations by the linoleic acid oxygenation product 9S-hydroxy 10E,12Z octadecadienoic acid (9-HODE)Biomed. Biochim. Acta.47(12)K17-21(1988)
| Cas No. | N/A | SDF | |
| المرادفات | (+)-α-Dimorphecolic Acid | ||
| Canonical SMILES | O[13C]([13CH2][13CH2][13CH2][13CH2][13CH2][13CH2][13CH2][13C@H](O)/[13CH]=[13CH]/[13CH]=[13CH]\[13CH2][13CH2][13CH2][13CH2][13CH3])=O | ||
| Formula | [13C]18H32O3 | M.Wt | 314.3 |
| الذوبان | DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.1817 mL | 15.9084 mL | 31.8167 mL |
| 5 mM | 0.6363 mL | 3.1817 mL | 6.3633 mL |
| 10 mM | 0.3182 mL | 1.5908 mL | 3.1817 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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