γ-Lindane |
| رقم الكتالوجGC48313 |
An insecticide and GABAA receptor antagonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 58-89-9
Sample solution is provided at 25 µL, 10mM.
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γ-Lindane is an organochloro insecticide that is an antagonist of GABAA receptors.1 It inhibits GABA-stimulated chloride uptake by membrane vesicles isolated from rat cerebral cortex (IC50 = 68 μM). It binds selectively to insect GABAA receptors over mammalian GABAA receptors in membrane preparations (IC50s = 1, 12, 505, 833, and 150-1, 675 nM for fruit fly, house fly, human, mouse, and rat, respectively).2,3 It binds to a human recombinant β3 homooligomer with similar selectivity as α1β3γ2-containing receptors, indicating that the binding site for γ-lindane on GABAA receptors is located on the β3 subunit (IC50s = 0.90, 21, and 306 nM for β3, α1β3γ2, and the native receptor, respectively).4 γ-Lindane blocks GABA- and glutamate-induced current responses in American cockroach neurons (IC50s = 1.74 and 148 nM, respectively).5 It is toxic to mice and adult house flies (LD50s = 40 and 5.5 mg/kg, respectively) and also kills head lice in vitro and inhibits hatching.4,6
1.Obata, T., Yamamura, H.I., Malatynska, E., et al.Modulation of ?-aminobutyric acid-stimulated chloride influx by bicycloorthocarboxylates, bicyclophosphorus esters, polychlorocycloalkanes and other cage convulsantsJ. Pharmacol. Exp. Ther.244(3)802-806(1988) 2.Hainzl, D., Cole, L.M., and Casida, J.E.Mechanisms for selective toxicity of fipronil insecticide and its sulfone metabolite and desulfinyl photoproductChem. Res. Toxicol.11(12)1529-1535(1998) 3.Llorens, J., SuÑol, C., Tussel, J.M., et al.Lindane inhibition of [35S]TBPS binding to the GABAA receptor in rat brainNeurotoxicol. Teratol.12(6)607-610(1990) 4.Ratra, G.S., Kamita, S.G., and Casida, J.E.Role of human GABAA receptor β3 subunit in insecticide toxicityToxicol. Appl. Pharmacol.172(3)233-240(2001) 5.Ihara, M., Ishida, C., Okuda, H., et al.Differential blocking actions of 4'-ethynyl-4-n-propylbicycloorthobenzoate (EBOB) and ?-hexachlorocyclohexane (?-HCH) on ?-aminobutyric acid- and glutamate-induced responses of American cockroach neuronsInvert. Neurosci.5(3-4)157-164(2005) 6.Meinking, T.L., Taplin, D., Kalter, D.C., et al.Comparative efficacy of treatments for pediculosis capitis infestationsArch. Dermatol.122(3)267-271(1986)
| Cas No. | 58-89-9 | SDF | |
| Canonical SMILES | Cl[C@@H]1[C@@H](Cl)[C@H](Cl)[C@H](Cl)[C@@H](Cl)[C@@H]1Cl | ||
| Formula | C6H6Cl6 | M.Wt | 290.8 |
| الذوبان | Chloroform: 50 mg/ml,Ethanol: >1 mg/ml,Methanol: >1 mg/ml,Water: 8.35 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 3.4388 mL | 17.1939 mL | 34.3879 mL |
| 5 mM | 0.6878 mL | 3.4388 mL | 6.8776 mL |
| 10 mM | 0.3439 mL | 1.7194 mL | 3.4388 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
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