ABT-418 hydrochloride |
| رقم الكتالوجGC60549 |
ABT-418 هيدروكلوريد هو ناهض قوي وانتقائي لـ nAChRs مع أنشطة تعزيز الإدراك ومزيل القلق
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Cas No.: 147388-83-8
Sample solution is provided at 25 µL, 10mM.
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ABT-418 hydrochloride is a potent and selective agonist of nAChRs with cognitive enhancing and anxiolytic activities. ABT-418 hydrochloride activates cholinergic channel and can be used for research of Alzheimer's disease[1][2].
ABT-418 hydrochloride (125.66 μg/kg; i.p.) induces a significant increase in the time spent by the rats in the open arms of the elevated plus maze[1].Acute administration of ABT-418 (125.66μg/kg; i.p.) also attenuates the anxiogenic-like effect elicited by withdrawal from chronic (-)-nicotine treatment[1].ABT-418 hydrochloride (0.6 mg/kg; i.p.; daily; for two weeks) effectively improves spatial memory in an animal model of ADHD[2].ABT-418 hydrochloride significantly enhances the cortical α4 and β2 nAChR subunits and the hippocampal α4 subunit expression[2]. Animal Model: Male SHRs (4-5 weeks old), attention deficit hyperactivity disorder (ADHD) model[2]
[1]. Brioni JD, et al. Anxiolytic-like effects of the novel cholinergic channel activator ABT-418. J Pharmacol Exp Ther. 1994 Oct;271(1):353-61. [2]. Guo T, et al. A comparative study of the effects of ABT-418 and methylphenidate on spatial memory in an animal model of ADHD. Neurosci Lett. 2012 Oct 18;528(1):11-5.
| Cas No. | 147388-83-8 | SDF | |
| Canonical SMILES | CN1[C@H](C2=CC(C)=NO2)CCC1.Cl | ||
| Formula | C9H15ClN2O | M.Wt | 202.68 |
| الذوبان | H2O : 11.9 mg/mL (58.71 mM; Need ultrasonic) | Storage | 4°C, away from moisture |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 4.9339 mL | 24.6694 mL | 49.3389 mL |
| 5 mM | 0.9868 mL | 4.9339 mL | 9.8678 mL |
| 10 mM | 0.4934 mL | 2.4669 mL | 4.9339 mL |
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Quality Control & SDS
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- Purity: >99.50%
- COA (Certificate Of Analysis)
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Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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