Amodiaquine-d10 (Synonyms: Camoquine-d10, Flavoquine-d10) |
| رقم الكتالوجGC45725 |
An internal standard for the quantification of amodiaquine
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1189449-70-4
Sample solution is provided at 25 µL, 10mM.
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Amodiaquine-d10 is intended for use as an internal standard for the quantification of amodiaquine by GC- or LC-MS. Amodiaquine is a prodrug form of the antimalarial compound N-desethyl amodiaquine .1,2 It is active against several strains of P. falciparum in vitro (EC50s = 0.23-0.52 nM) and exhibits a synergistic effect when used in combination with N-desethyl amodiaquine.1 Amodiaquine dose-dependently inhibits development of parasitemia in a mouse model of P. berghei infection.3
|1. Mariga, S.T., Gil, J.P., Sisowath, C., et al. Synergism between amodiaquine and its major metabolite, desethylamodiaquine, against Plasmodium falciparum in vitro. Antimicrob. Agents Chemother. 48(11), 4089-4096 (2004).|2. SÁ, J.M., Chong, J.L., and Wellems, T.E. Malaria drug resistance: New observations and developments. Essays Biochem. 51, 137-160 (2014).|3. Jacobs, R.L., Alling, D.W., and Cantrell, W.F. An evaluation of antimalarial combinations against Plasmodium berghei in the mouse. J. Parasitol. 49(6), 920-925 (1963).
| Cas No. | 1189449-70-4 | SDF | |
| المرادفات | Camoquine-d10, Flavoquine-d10 | ||
| Canonical SMILES | OC(C=C1)=C(CN(C([2H])([2H])C([2H])([2H])[2H])C([2H])([2H])C([2H])([2H])[2H])C=C1NC2=CC=NC3=C2C=CC(Cl)=C3 | ||
| Formula | C20H12ClD10N3O | M.Wt | 365.9 |
| الذوبان | DMSO : 66.67 mg/mL (182.20 mM; ultrasonic and adjust pH to 3 with 1M HCl) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.733 mL | 13.6649 mL | 27.3299 mL |
| 5 mM | 0.5466 mL | 2.733 mL | 5.466 mL |
| 10 mM | 0.2733 mL | 1.3665 mL | 2.733 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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