الصفحة الرئيسية>>Signaling Pathways>> Metabolism>> Carbohydrate Metabolism>>BAY-588

BAY-588

رقم الكتالوجGC19000

BAY-588 is a glucose transporter inhibitor and derivative of BAY-876 .

Products are for research use only. Not for human use. We do not sell to patients.

BAY-588 التركيب الكيميائي

Cas No.: 1799759-24-2

الحجم السعر المخزون الكميّة
1mg
63٫00
متوفر
5mg
241٫00
متوفر
10mg
452٫00
متوفر

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مراجعات العميل

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  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

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Sample solution is provided at 25 µL, 10mM.

Description of BAY-588

BAY-588 is a glucose transporter inhibitor and derivative of BAY-876 . It selectively inhibits glucose transporter 4 (Glut4), Glut1, and Glut3 over Glut2 with IC50 values of 0.5, 1.18, 5.47, and >10 μM, respectively, in CHO cells expressing human recombinant transporters.

Chemical Properties of BAY-588

Cas No. 1799759-24-2 SDF
Chemical Name N4-[1-[[4-(1,1-dimethylethyl)phenyl]methyl]-5-methyl-3-(trifluoromethyl)-1H-pyrazol-4-yl]-7-fluoro-2,4-quinolinedicarboxamide
Canonical SMILES FC1=CC=C2C(N=C(C(N)=O)C=C2C(NC3=C(C)N(CC4=CC=C(C(C)(C)C)C=C4)N=C3C(F)(F)F)=O)=C1
Formula C27H25F4N5O2 M.Wt 527.5
الذوبان DMF: 20 mg/ml,DMSO: 20 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml,Ethanol: 1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of BAY-588

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.8957 mL 9.4787 mL 18.9573 mL
5 mM 0.3791 mL 1.8957 mL 3.7915 mL
10 mM 0.1896 mL 0.9479 mL 1.8957 mL
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** عند إعداد حلول المخزون، دائمًا استخدم الوزن الجزيئي الخاص بالدفعة للمنتج على ملصق القارورة MSDS / CoA (متوفر عبر الإنترنت).

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In vivo Formulation Calculator (Clear solution) of BAY-588

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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