Berberine-d6 (chloride) (Synonyms: BBR-d6, Umbellatine-d6) |
| رقم الكتالوجGC49387 |
An internal standard for the quantification of berberine
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Berberine-d6 is intended for use as an internal standard for the quantification of berberine by GC- or LC-MS. Berberine is an isoquinoline alkaloid that has been found in C. fenestratum and has diverse biological activities.1,2,3,4,5 It induces frameshift mutations and gene crossovers in haploid and diploid strains of S. cerevisiae, respectively, in the exponential growth phase when used at a concentration of 50 µg/ml.2 Berberine is active against the S. aureus strains ATCC 25922 and NCTC 8530 (MIC = 250 µg/ml for both).3 It decreases contusion volume, ventricle enlargement, and neurological deficits in a mouse model of controlled cortical impact-induced traumatic brain injury (TBI) when administered at a dose of 10 mg/kg.4 Berberine (50 mg/kg) reduces serum LDL cholesterol levels in hamsters fed a high-fat high-cholesterol diet.5
1.Malhotra, S., Taneja, S.C., and Dhar, K.L.Minor alkaloid from Coscinium fenestratumPhytochem.28(7)1998-1999(1989) 2.Pasqual, M.S., Lauer, C.P., Moyna, P., et al.Genotoxicity of the isoquinoline alkaloid berberine in prokaryotic and eukaryotic organismsMutat. Res.286(2)243-252(1993) 3.Iwasa, K., Kamigauchi, M., Ueki, M., et al.Antibacterial activity and structure-activity relationships of berberine analogsEur. J. Med. Chem.31(6)469-478(1996) 4.Chen, C.C., Hung, T.H., Lee, C.Y., et al.Berberine protects against neuronal damage via suppression of glia-mediated inflammation in traumatic brain injuryPLoS One9(12)e115694(2014) 5.Kong, W., Wei, J., Abidi, P., et al.Berberine is a novel cholesterol-lowering drug working through a unique mechanism distinct from statinsNat. Med.10(12)1344-1351(2004)
| Cas No. | N/A | SDF | |
| المرادفات | BBR-d6, Umbellatine-d6 | ||
| Canonical SMILES | [2H]C([2H])([2H])OC1=CC=C2C(C=[N+]3CCC4=C(C3=C2)C=C5OCOC5=C4)=C1OC([2H])([2H])[2H].[Cl-] | ||
| Formula | C20H12D6NO4·Cl | M.Wt | 377.9 |
| الذوبان | DMSO: slightly soluble,Methanol: slightly soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6462 mL | 13.231 mL | 26.462 mL |
| 5 mM | 0.5292 mL | 2.6462 mL | 5.2924 mL |
| 10 mM | 0.2646 mL | 1.3231 mL | 2.6462 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
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