β-Amyloid 1-28 (Amyloid β-Protein (1-28)) (Synonyms: Amyloid β-Protein (1-28)) |
| رقم الكتالوجGC31171 |
&beta؛ -Amyloid 1-28 (Amyloid &beta؛ -Protein (1-28)) عبارة عن β ؛ - جزء بروتين أميلويد متورط في ربط المعادن.
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Cas No.: 109770-29-8
Sample solution is provided at 25 µL, 10mM.
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β-Amyloid (1-28) is a β-Amyloid protein fragment involved in metal binding. Beta-amyloid is a peptide that forms amyloid plaques in the brains of Alzheimer's disease (AD) patients.
β-Amyloid (1-28) fragment is considered as valid models to examine the contribution of the key histidine residues (His , His in mouse and His , His , His in human fragments) to the Ab-Cu2+ interaction[1]. Copper binds to β-Amyloid (1-28) at pH 7.4 with an affinity of Ka10 7 M-1[2].
[1]. Kowalik-Jankowska T, et al. Coordination abilities of the 1-16 and 1-28 fragments of beta-amyloid peptide towards copper(II) ions: a combined potentiometric and spectroscopic study. J Inorg Biochem. 2003 Jul 1;95(4):270-82. [2]. Syme CD, et al. Copper binding to the amyloid-beta (Abeta) peptide associated with Alzheimer's disease: folding, coordination geometry, pH dependence, stoichiometry, and affinity of Abeta-(1-28): insights from a range of complementary spectroscopic techniques. J Biol Chem. 2004 Apr 30;279(18):18169-77.
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