الصفحة الرئيسية>>Signaling Pathways>> DNA Damage/DNA Repair>> CDK>>Bisindolylmaleimide X (hydrochloride)

Bisindolylmaleimide X (hydrochloride) (Synonyms: BIM X, Ro 31-8425)

رقم الكتالوجGC18354

Bisindolylmaleimide X (هيدروكلوريد) (BIM-X هيدروكلوريد) هو مثبط قوي وانتقائي لبروتين كيناز سي (PKC).

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Bisindolylmaleimide X (hydrochloride) التركيب الكيميائي

Cas No.: 145317-11-9

الحجم السعر المخزون الكميّة
1mg Please Inquire Please Inquire
5mg
135٫00
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Sample solution is provided at 25 µL, 10mM.

Description of Bisindolylmaleimide X (hydrochloride)

Bisindolylmaleimide X is a cell-permeable, reversible, ATP-competitive protein kinase C (PKC) inhibitor (IC50 = 15 nM, rat brain PKC). It has been shown to inhibit PKCα, βI, βII, γ, and ε with IC50 values of 8, 8, 14, 13, and 39 nM, respectively. It has also been identified as an inhibitor of Cdk2 (IC50 = 200 nM) and GSK3α/β. This compound has been used to activate mesenchymal stem cells, increase the surface expression of homing ligands that bind to intercellular adhesion molecule 1, and target delivery of these cells to sites of inflammation.

Chemical Properties of Bisindolylmaleimide X (hydrochloride)

Cas No. 145317-11-9 SDF
المرادفات BIM X, Ro 31-8425
Chemical Name 3-[8-(aminomethyl)-6,7,8,9-tetrahydropyrido[1,2-a]indol-10-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione, monohydrochloride
Canonical SMILES O=C(N1)C(C2=CN(C)C3=C2C=CC=C3)=C(C4=C5N(CCC(CN)C5)C6=C4C=CC=C6)C1=O.Cl
Formula C26H24N4O2.HCl M.Wt 461
الذوبان DMSO : 20.83 mg/mL (45.19 mM; Need ultrasonic); H2O : < 0.1 mg/mL (insoluble) Storage 4°C, protect from light
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of Bisindolylmaleimide X (hydrochloride)

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1 mg 5 mg 10 mg
1 mM 2.1692 mL 10.846 mL 21.692 mL
5 mM 0.4338 mL 2.1692 mL 4.3384 mL
10 mM 0.2169 mL 1.0846 mL 2.1692 mL
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In vivo Formulation Calculator (Clear solution) of Bisindolylmaleimide X (hydrochloride)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 18 reference(s) in Google Scholar.)

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