Bombesin |
| رقم الكتالوجGC14014 |
يلعب Bombesin ، وهو رباعي الببتيد ، دورًا مهمًا في إطلاق الجاسترين وتنشيط مستقبلات البروتين G
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Cas No.: 31362-50-2
Sample solution is provided at 25 µL, 10mM.
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Bombesin is a 14-amino acid peptide that belongs to the Bombesin-related peptide family and plays an important role in gastrin release and G protein receptor activation[1, 2]. Bombesin, with a carboxyl terminus ending in Gly-His-Leu-Met-NH2, was originally isolated from the skin of the European bell toad (Bombina bombina). Its homologous peptides (such as gastrin-releasing peptide (GRP) and neuromedin B (NMB)) were later found in mammals[3]. Bombesin is a multifunctional neuropeptide that can stimulate gastric and pancreatic secretion, gastrointestinal hormone release, gallbladder contraction, and bronchial contraction[4]. Bombesin is present in amphibian gastric endocrine cells, avian glandular stomach endocrine cells, and avian brain. In mammals, Bombesin is mainly present in nerve cells and fibers[5]. Bombesin can stimulate nuclear factor κB activation and the expression of proangiogenic factors in prostate cancer cells[6].
References:
[1] Vigna S R, Thorndyke M C. Bombesin[M]//The comparative physiology of regulatory peptides. Dordrecht: Springer Netherlands, 1989: 34-60.
[2] LaPelusa A, Jan A. Biochemistry, bombesin[J]. 2019.
[3] Tian Z. QUB-1073: A Bioactice Peptide from the Skin Secretion of Phyllomedusa Rohdei[D]. Queen's University Belfast. Faculty of Medicine, Health and Life Sciences, December, 2018.
[4] Cho W K. Role of the neuropeptide, bombesin, in bile secretion[J]. The Yale Journal of Biology and Medicine, 1997, 70(4): 409.
[5] Chejfec G, Lee I, Warren W H, et al. Bombesin in human neuroendocrine (NE) neoplasms[J]. Peptides, 1985, 6: 107-112.
[6] Levine L, Lucci III J A, Pazdrak B, et al. Bombesin stimulates nuclear factor κB activation and expression of proangiogenic factors in prostate cancer cells[J]. Cancer research, 2003, 63(13): 3495-3502.
| Cas No. | 31362-50-2 | SDF | |
| Chemical Name | (S,Z)-N'1-((5S,6Z,8S,9Z,11S,12Z,15Z,17S,18Z,20S,21Z,23S,24Z,26S,27Z,29S,30Z,33Z,35S,36Z,38S)-11-((1H-imidazol-5-yl)methyl)-23-((1H-indol-3-yl)methyl)-43-amino-7,10,13,16,19,22,25,28,31,34,37-undecahydroxy-5-(hydroxy(imino)methyl)-29-(2-hydroxy-2-iminoethy | ||
| Canonical SMILES | CC(C[C@@](/N=C(O)/[C@](/N=C(O)/[C@](/N=C(O)/[C@]1([H])CCC(O)=N1)([H])CCC(O)=N)([H])CCCNC(N)=N)([H])/C(O)=N/C/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/C/C(O)=N/[C@@](/C(O)=N/[C@@](/C(O)=N/[C@@](C(O)=N)([H])CCSC)([H])CC(C | ||
| Formula | C71H110N24O18S | M.Wt | 1619.85 |
| الذوبان | Soluble to 1 mg/ml in sterile water | Storage | Desiccate at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 617.3 μL | 3.0867 mL | 6.1734 mL |
| 5 mM | 123.5 μL | 617.3 μL | 1.2347 mL |
| 10 mM | 61.7 μL | 308.7 μL | 617.3 μL |
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Quality Control & SDS
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- Purity: >99.50%
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Average Rating: 5 (Based on Reviews and 4 reference(s) in Google Scholar.)
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