C-telopeptide |
| رقم الكتالوجGC30509 |
يتم إطلاق C-telopeptide ، وهو ببتيد متصالب من النوع الأول من الكولاجين ، أثناء ارتشاف العظم ويرتبط بكثافة المعادن في العظام (BMD)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 162929-64-8
Sample solution is provided at 25 µL, 10mM.
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C-telopeptide is the cross-linked C-telopeptide of type I collagen[1]. During bone resorption, C-telopeptide is degraded by cathepsin K to cleave serum s-NTX from the amino (N)-terminal end and C-telopeptide from the carboxy (C)-terminal end. s-NTX and C-telopeptide make their way into the circulation, where their concentration provides information regarding the level of ongoing bone resorption[2]. C-telopeptide is a reference marker of bone resorption, which enhances understanding of the clinical utility of bone turnover markers (BTM)[2-3].
References:
[1] Rathnayake H, Lekamwasam S, Wickramatilake C, De Zoysa E, Lenora J. Age-related trends and reference intervals of cross-linked C-telopeptide of type I collagen and procollagen type I N-propeptide from a reference population of Sri Lankan adult women. Arch Osteoporos. 2021;16(1):164.
[2] Bauer D, Krege J, Lane N, et al. National Bone Health Alliance Bone Turnover Marker Project: current practices and the need for US harmonization, standardization, and common reference ranges. Osteoporos Int. 2012;23(10):2425-2433.
[3] Comparison of two automated assays of BTM (CTX and P1NP) and reference intervals in a Danish population.
| Cas No. | 162929-64-8 | SDF | |
| Canonical SMILES | Glu-Lys-Ala-His-Asp-Gly-Gly-Arg | ||
| Formula | C34H56N14O13 | M.Wt | 868.9 |
| الذوبان | Soluble in Water | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.1509 mL | 5.7544 mL | 11.5088 mL |
| 5 mM | 230.2 μL | 1.1509 mL | 2.3018 mL |
| 10 mM | 115.1 μL | 575.4 μL | 1.1509 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
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