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Nicotine (Synonyms: DL-Nicotine)

رقم الكتالوجGC14043

A nicotinic acetylcholine receptor (nAChR) agonist

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Nicotine التركيب الكيميائي

Cas No.: 22083-74-5

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
34٫00
متوفر
100mg
103٫00
متوفر
250mg
246٫00
متوفر
500mg
362٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 2 publications

Product Documents

Quality Control & SDS

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Background

(±)-Nicotine is the racemic mixture of the dominant alkaloid found in tobacco plants. It acts as an agonist at neuronal nicotinic acetylcholine receptors (nAChRs; Kis = 481 and 11.1 nM for α3β4 and α4β2 subtypes, respectively) and possesses addictive and teratogenic properties.1 (−)-(S)-Nicotine is significantly more active at binding nAChRs compared to the (+)-(R) antipode, thus nicotine is typically synthesized as (−)-(S)-nicotine with only 0.2-1% of the (+)-(R) isomer present.2
References
1. Zaveri, N., Jiang, F., Olsen, C., et al. Novel α3β4 nicotinic acetylcholine receptor-selective ligands. Discovery, structure-activity studies, and pharmacological evaluation. J. Med. Chem. 53(22), 8187-8191 (2010).
2. Clayton, P., Lu, A., and Bishop, L. The pyrolysis of (−)-(S)-nicotine: Racemization and decomposition. Chirality 22(4), 442-446 (2010).

Chemical Properties

Cas No. 22083-74-5 SDF
المرادفات DL-Nicotine
Chemical Name (R)-3-(1-methylpyrrolidin-2-yl)pyridine
Canonical SMILES CN1[C@@H](C2=CC=CN=C2)CCC1
Formula C10H14N2 M.Wt 162.23
الذوبان >6.8mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 6.1641 mL 30.8204 mL 61.6409 mL
5 mM 1.2328 mL 6.1641 mL 12.3282 mL
10 mM 0.6164 mL 3.082 mL 6.1641 mL
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Related Video

    Nicotine-GlpBio

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Average Rating: 5 ★★★★★ (Based on Reviews and 33 reference(s) in Google Scholar.)

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