(E)-Ferulic acid-d3 (Synonyms: (E)-Coniferic acid-d3) |
| رقم الكتالوجGC66371 |
(E) - حمض الفيروليك - d3 ((E) - حمض الكونيريك - d3) هو الديوتيريوم المسمى (E) - حمض الفيروليك. (هـ) - حمض الفيروليك هو أيزومر لحمض الفيروليك وهو مركب عطري وفير في جدران الخلايا النباتية. (E) - يتسبب حمض الفيروليك في فسفرة β ؛ -كاتينين ، مما يؤدي إلى تدهور البروتوزومال من β ؛ -كاتينين ويزيد من التعبير عن العامل المؤيد للاستماتة Bax ويقلل من التعبير عن عامل البقاء على قيد الحياة. (E) - يظهر حمض الفيروليك قدرة قوية على إزالة أنواع الأكسجين التفاعلية (ROS) ويمنع بيروكسيد الدهون. (E) - يمارس حمض الفيروليك كلا من التأثيرات المضادة للتكاثر والهجرة في خط خلايا سرطان الرئة البشرية H1299.
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Cas No.: 860605-59-0
Sample solution is provided at 25 µL, 10mM.
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(E)-Ferulic acid-d3 ((E)-Coniferic acid-d3) is the deuterium labeled (E)-Ferulic acid. (E)-Ferulic acid is a isomer of Ferulic acid which is an aromatic compound, abundant in plant cell walls. (E)-Ferulic acid causes the phosphorylation of β-catenin, resulting in proteasomal degradation of β-catenin and increases the expression of pro-apoptotic factor Bax and decreases the expression of pro-survival factor survivin. (E)-Ferulic acid shows a potent ability to remove reactive oxygen species (ROS) and inhibits lipid peroxidation. (E)-Ferulic acid exerts both anti-proliferation and anti-migration effects in the human lung cancer cell line H1299[1].
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
| Cas No. | 860605-59-0 | SDF | |
| المرادفات | (E)-Coniferic acid-d3 | ||
| Formula | C10H7D3O4 | M.Wt | 197.2 |
| الذوبان | Storage | Store at -20°C | |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 5.071 mL | 25.355 mL | 50.7099 mL |
| 5 mM | 1.0142 mL | 5.071 mL | 10.142 mL |
| 10 mM | 0.5071 mL | 2.5355 mL | 5.071 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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