الصفحة الرئيسية>>Peptides>>Fetuin, Fetal Bovine Serum

Fetuin, Fetal Bovine Serum

رقم الكتالوجGC60166

فيتوين، المصل الجنيني للبقر هو بروتين غليكوبروتين من مصل الجنين البقرة، والذي يعد في كثير من الأحيان مكملاً هاماً للعديد من وسائط خالية من المصل.

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Fetuin, Fetal Bovine Serum التركيب الكيميائي

Cas No.: 9014-81-7

الحجم السعر المخزون الكميّة
50mg
79٫00
متوفر
100mg
140٫00
متوفر
250mg
230٫00
متوفر
500mg
396٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 2 publications

Product Documents

Quality Control & SDS

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Protocol

Animal experiment [1]:

Animal models

Male nude mice

Preparation Method

The prostate adenocarcinoma cell PC-3 (2 million cells) were injected on the upper half of the dorsal thorax of the mice. The tumors were allowed to grow for 6 weeks. The mice in the control group (no treatment) received 0.1 ml saline intraperitoneally for 5 days and the mice in the treated group received 50 mg/kg Fetuin, Fetal Bovine Serum. Treatment started the day after tumor inoculation for 5 days. Six weeks after the inoculation of tumor, mice were killed and tumors were removed and weighed.

Dosage form

Intraperitoneal injection, 50 mg/kg/d for 5d

Applications

Tumors (average weight 325 mg) developed in 13 of 13 mice in the control group (treated with saline), none of the nine mice treated with fetuin (50 mg/kg) developed any tumor.

References:

[1]: Yu C L, Tsai M H. Fetal fetuin selectively induces apoptosis in cancer cell lines and shows anti-cancer activity in tumor animal models[J]. Cancer letters, 2001, 166(2): 173-184.

Background

فيتوين، المصل الجنيني للبقر هو بروتين غليكوبروتين من مصل الجنين البقري، والذي يعد غالبًا مكملاً هامًا للعديد من وسائط خالية من المصل. تحضير فيتوئين البقر قد عطَّل نشاط إنزيم التربسين وزاد من ارتباط الخلاية والانقسام والتما differentiation في أُغْرِظة ثقافة مختلفة [1]. تم تأسیس فیتینات كعائِلى داخِلىَّ ضمْن سُپَیرفاميلی کستاتین [2].

فيتوين، مصل الجنين البقري له نشاط على سلالة S3 من خلايا هيلة في تعزيز التثبيت والتمدد (الانسطاح) على الزجاج [3] . حفزت مستحضرات فيتوين، مصل الجنين البقرية نمو مجموعة من الخلايا الثديية من أصول مختلفة. حفَّز فيتوِئِــــــْن، المُصَلُّ المأخود من جِنْى بَقَرِى (30-960 µg/ml) نمو خلاية Hela [4] . أظهر أن آبار شكل LNCaP التى تم تحضيرها باستخدام فيتوِئِـــْن، المُصَلُّ المأخود من جِنْى بَقَرِى صفات احتضانية [5] .

زادت الفيتوين والمصل الجنيني للبقر نسبة البقاء حتى 141٪ في نموذج سرطان الدم P388. في نموذج سرطان البروستاتا PC-3 للحيوانات، يبدو أنَّ فعالية الفيتوين (50 مغ/كغ) تثبط بشكل كامل تكوُّن سرطان البروستاتا على فئران [5].

References:
[1]. Nie Z. Fetuin: its enigmatic property of growth promotion[J]. American Journal of Physiology-Cell Physiology, 1992, 263(3): C551-C562.
[2]. Brown W M, Dziegielewska K M, Saunders N R, et al. Fetuin坼an old friend revisited[J]. Bioessays, 1992, 14(11): 749-755.
[3]. Fisher H W, Puck T T, Sato G. Molecular growth requirements of single mammalian cells: The action of fetuin in promoting cell attachment to glass[J]. Proceedings of the National Academy of Sciences, 1958, 44(1): 4-10.
[4]. Marr A G M, Owen J A, Wilson G S. Studies on the growth-promoting glycoprotein fraction of foetal calf serum[J]. Biochimica et Biophysica Acta, 1962, 63(2): 276-285.
[5]. Yu C L, Tsai M H. Fetal fetuin selectively induces apoptosis in cancer cell lines and shows anti-cancer activity in tumor animal models[J]. Cancer letters, 2001, 166(2): 173-184.

Chemical Properties

Cas No. 9014-81-7 SDF
Formula M.Wt
الذوبان Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.
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Average Rating: 5 ★★★★★ (Based on Reviews and 13 reference(s) in Google Scholar.)

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