الصفحة الرئيسية>>Signaling Pathways>> Others>> Fluorescent Probes>>FFN-102 (trifluoroacetate salt)

FFN-102 (trifluoroacetate salt)

رقم الكتالوجGC18579

FFN-102 is a fluorescent false neurotransmitter (FFN) that is a substrate for the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2).

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FFN-102 (trifluoroacetate salt) التركيب الكيميائي

Cas No.: 1234064-11-9

الحجم السعر المخزون الكميّة
1mg
46٫00
متوفر
5mg
181٫00
متوفر
10mg
333٫00
متوفر
25mg
707٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of FFN-102 (trifluoroacetate salt)

FFN-102 is a fluorescent false neurotransmitter (FFN) that is a substrate for the dopamine transporter (DAT) and vesicular monoamine transporter 2 (VMAT2). It is a pH-dependent fluorescent probe that labels dopamine cell bodies, axons, and presynaptic terminals. It can also be used to monitor dopamine exocytosis. It has a pKa of 6.2 and displays pH-dependent excitation spectra of 340 and 370 nm at pH 5 and 7.4, respectively, which correspond to vesicular and cytoplasmic pH values. The emission spectrum of FFN-102 is pH-independent at 453 nm, but the intensity of emission is pH-dependent with a higher intensity at a pH of 7.4. FFN-102 inhibits DAT (13.6% at a concentration of 10 uM) and the serotonin (5-HT) receptor subtype 5-HT2c (Ki = ~3 uM) but does not bind to 37 other central nervous system receptors and transporters, including dopamine receptors, up to a concentration of 10 uM.

Chemical Properties of FFN-102 (trifluoroacetate salt)

Cas No. 1234064-11-9 SDF
Chemical Name 4-(2-aminoethyl)-6-chloro-7-hydroxy-2H-1-benzopyran-2-one 2,2,2-trifluoroacetate
Canonical SMILES OC1=C(Cl)C=C(C(CCN)=CC(O2)=O)C2=C1.FC(F)(C(O)=O)F
Formula C11H10ClNO3.CF3COOH M.Wt 353.7
الذوبان DMF: 20 mg/ml,DMSO: 20 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of FFN-102 (trifluoroacetate salt)

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1 mg 5 mg 10 mg
1 mM 2.8273 mL 14.1363 mL 28.2725 mL
5 mM 0.5655 mL 2.8273 mL 5.6545 mL
10 mM 0.2827 mL 1.4136 mL 2.8273 mL
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In vivo Formulation Calculator (Clear solution) of FFN-102 (trifluoroacetate salt)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

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