Fluocinolone Acetonide (Synonyms: NSC 92339) |
| رقم الكتالوجGC11257 |
Fluocinolone Acetonide هو مشتق من الجلوكورتيكويد يستخدم موضعياً في علاج اضطرابات الجلد المختلفة.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 67-73-2
Sample solution is provided at 25 µL, 10mM.
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Fluocinolone Acetonide is a glucocorticoid derivative used topically in the treatment of various skin disorders.Target: Glucocorticoid ReceptorFluocinolone acetonide is a corticosteroid primarily used in dermatology to reduce skin inflammation and relieve itching. It is a synthetic hydrocortisone derivative. The fluorine substitution at position 9 in the steroid nucleus greatly enhances its activity. A typical dosage strength used in dermatology is 0.01-0.025%. One such cream is sold under the brand name Flucort-N and includes the antibiotic neomycin. The Glucocorticoid Receptor(GR) binding affinity (IC50) for Fluocinolone Acetonide(FA) was 2.0 nM, respectively. The values is similar to the GR transactivation EC50 of 0.7 nM for FA, respectively [1, 2].
References:
[1]. http://en.wikipedia.org/wiki/Fluocinolone_acetonide
[2]. Nehme, A., et al., Glucocorticoids with different chemical structures but similar glucocorticoid receptor potency regulate subsets of common and unique genes in human trabecular meshwork cells. BMC Med Genomics, 2009. 2: p. 58.
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