(-)-Menthol (Synonyms: L-Menthol, (1R,2S,5R)-(-)-Menthol, NSC 62788) |
| رقم الكتالوجGC34951 |
(-) - المنثول هو أحد المكونات الرئيسية لزيت النعناع الذي يربط وينشط مستقبلات الميلاستاتين المحتمل للمستقبلات العابرة 8 (TRPM8) ، وهي قناة كاتيون غير انتقائية قابلة للنفاذ Ca2 ، لزيادة [Ca2 +] iنشاط انتيتومور
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Cas No.: 2216-51-5
Sample solution is provided at 25 µL, 10mM.
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(-)-Menthol is a key component of peppermint oil that binds and activates transient receptor potential melastatin 8 (TRPM8), a Ca2+-permeable nonselective cation channel, to increase [Ca2+]i[1]. Antitumor activity[1]. TRPM8[1]
(-)-Menthol (Menthol ) per se does not exhibit antiproliferative activity, but it is able to enhance 1α,25(OH)2D3-mediated growth inhibition in LNCaP cells. At high (-)-Menthol concentrations above 1.6 mM, the cells begin to detach from the culture dish[1]. (-)-Menthol (0.8 mM) can increase [Ca2+]i via transmembrane influx or store release pathways. Peak increase in [Ca2+]i was 102.3±39 nM (n=3) in (-)-Menthol alone and 124.5±51 nM (n=3) in combination of 1α,25(OH)2D3 with (-)-Menthol, respectively[1].Combination of 1α,25(OH)2D3 with (-)-Menthol (0.8 mM) cooperatively modulates bcl-2 and p21 expression[1].
[1]. Park EJ, et al. Menthol Enhances an Antiproliferative Activity of 1alpha,25-Dihydroxyvitamin D(3) in LNCaP Cells. J Clin Biochem Nutr. 2009 Mar;44(2):125-30.
| Cas No. | 2216-51-5 | SDF | |
| المرادفات | L-Menthol, (1R,2S,5R)-(-)-Menthol, NSC 62788 | ||
| Canonical SMILES | O[C@H]1[C@H](C(C)C)CC[C@@H](C)C1 | ||
| Formula | C10H20O | M.Wt | 156.27 |
| الذوبان | DMSO: 100 mg/mL (639.92 mM) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.3992 mL | 31.9959 mL | 63.9918 mL |
| 5 mM | 1.2798 mL | 6.3992 mL | 12.7984 mL |
| 10 mM | 0.6399 mL | 3.1996 mL | 6.3992 mL |
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Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
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- Purity: >98.00%
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Average Rating: 5 (Based on Reviews and 17 reference(s) in Google Scholar.)
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