الصفحة الرئيسية>>Nucleotides/Nucleosides>>5-Chlorouracil

5-Chlorouracil

رقم الكتالوجGC45357

 

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5-Chlorouracil التركيب الكيميائي

Cas No.: 1820-81-1

الحجم السعر المخزون الكميّة
5g
49٫00
متوفر
10g
90٫00
متوفر
25g
161٫00
متوفر
50g
298٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of 5-Chlorouracil

5-Chlorouracil is a chlorinated derivative of the pyrimidine nucleoside base uracil . In vivo, it is converted into chlorodeoxyuridine, which is mutagenic and genotoxic.1 Uracil is chlorinated at the 5 position in a cell-free myeloperoxidase, peroxide, and chloride system in which hypochlorous acid is formed.2 5-Chlorouracil has been found in human neutrophils stimulated with phorbol 12-myristate 13-acetate in vitro and in inflammatory human exudate isolated from sites of superficial infection. Levels of 5-chlorouracil are increased in exudate isolated from the site of inflammation in a rat model of carrageenan-induced inflammation and in patient-derived human atherosclerotic aortic tissue.3,4

References

Chemical Properties of 5-Chlorouracil

Cas No. 1820-81-1 SDF
Canonical SMILES O=C1NC(NC=C1Cl)=O
Formula C4H3ClN2O2 M.Wt 146.5
الذوبان DMF: 8 mg/ml,DMSO: 0.8 mg/ml,Ethanol: 53 mg/ml,PBS (pH 7.2): 60 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of 5-Chlorouracil

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 6.8259 mL 34.1297 mL 68.2594 mL
5 mM 1.3652 mL 6.8259 mL 13.6519 mL
10 mM 0.6826 mL 3.413 mL 6.8259 mL
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In vivo Formulation Calculator (Clear solution) of 5-Chlorouracil

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Average Rating: 5 ★★★★★ (Based on Reviews and 10 reference(s) in Google Scholar.)

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