Cabazitaxel-d9 (Synonyms: XRP6258-d9; RPR-116258A-d9; taxoid XRP6258-d9) |
| رقم الكتالوجGC45395 |
Cabazitaxel-d9 هو الديوتيريوم المسمى Cabazitaxel. Cabazitaxel هو مشتق شبه اصطناعي من التاكسويد الطبيعي 10-deacetylbaccatin III مع نشاط محتمل لمضادات الأورام.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1383572-19-7
Sample solution is provided at 25 µL, 10mM.
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Cabazitaxel-d9 is intended for use as an internal standard for the quantification of cabazitaxel by GC- or LC-MS. Cabazitaxel is a second generation semisynthetic taxane derived from 10-deacetylbaccatin III .1 It stabilizes microtubule assembly by reducing lag time for tubulin assembly (LT50 = 100 nM) and the rate of cold-induced microtubule depolymerization (IC50s = 100-250 nM) in vitro. Cabazitaxel inhibits proliferation of P388, HL-60, Calc18, and KB cells (IC50s = 4-41 nM), as well as P-glycoprotein-expressing, drug-resistant versions of these cell lines (IC50s = 16-414 nM). In vivo, cabazitaxel dose-dependently reduces tumor growth in docetaxel-susceptible N87 human gastric carcinoma and docetaxel-resistant UISO BCA-1 breast cancer mouse xenograft models. Formulations containing cabazitaxel have been used in combination with prednisone in the treatment of hormone-refractory metastatic prostate cancer.
References
1. Vrignaud, P., SÉmiond, D., Lejeune, P., et al. Preclinical antitumor activity of cabazitaxel, a semisynthetic taxane active in taxane-resistant tumors. Clin. Cancer Res. 19(11), 2973-2983 (2013).
| Cas No. | 1383572-19-7 | SDF | |
| المرادفات | XRP6258-d9; RPR-116258A-d9; taxoid XRP6258-d9 | ||
| Canonical SMILES | CO[C@@H](C[C@]1(OC[C@]1([C@]2([C@@H]3OC(C4=CC=CC=C4)=O)[H])OC(C)=O)[H])[C@]2(C([C@@H](C(C(C)5C)=C([C@H](C[C@]53O)OC([C@@H]([C@H](C6=CC=CC=C6)NC(OC(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=O)O)=O)C)OC)=O)C | ||
| Formula | C45H48D9NO14 | M.Wt | 845 |
| الذوبان | DMSO: soluble,Methanol: soluble | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.1834 mL | 5.9172 mL | 11.8343 mL |
| 5 mM | 0.2367 mL | 1.1834 mL | 2.3669 mL |
| 10 mM | 0.1183 mL | 0.5917 mL | 1.1834 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 34 reference(s) in Google Scholar.)
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