Griseofulvin-d3 |
| رقم الكتالوجGC48688 |
An internal standard for the quantification of griseofulvin
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1279033-22-5
Sample solution is provided at 25 µL, 10mM.
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Griseofulvin-d3 is intended for use as an internal standard for the quantification of griseofulvin by GC- or LC-MS. Griseofulvin is a fungal metabolite that has been found in Penicillium and has diverse biological activities.1 It is active against clinical isolates of the dermatophytes T. rubrum, T. tonsurans, and M. canis (MICs = 0.0078-0.0156, 1-4, and 0.5-2 µg/ml, respectively).2 Griseofulvin binds to tubulin (Kd = 300 µM) and reduces the growth rate and shortening rate of isolated bovine brain microtubulin, indicating stabilization of microtubule dynamics, when used at concentrations ranging from 0.5 to 20 µM.3 It induces abnormal microtubule polymerization and cell cycle arrest at the G2/M phase in HT-29 cells when used at a concentration of 20 µM.4 Griseofulvin (30 mg/kg), alone or in combination with nocodazole , reduces tumor growth in a COLO 205 mouse xenograft model. Formulations containing griseofulvin have been used in the treatment of fungal infections.
1.Singh, P., Rathinasamy, K., Mohan, R., et al.Microtubule assembly dynamics: An attractive target for anticancer drugsIUBMB Life60(6)368-375(2008) 2.Brilhante, R.S.N., Correia, E.E.M., Guedes, G.M.M., et al.In vitro activity of azole derivatives and griseofulvin against planktonic and biofilm growth of clinical isolates of dermatophytesMycoses61(7)449-454(2018) 3.Panda, D., Rathinasamy, K., Santra, M.K., et al.Kinetic suppression of microtubule dynamic instability by griseofulvin: Implications for its possible use in the treatment of cancerProc. Natl. Acad. Sci. USA102(28)9878-9883(2005) 4.Ho, Y.-S., Duh, J.-S., Jeng, J.-H., et al.Griseofulvin potentiates antitumorigenesis effects of nocodazole through induction of apoptosis and G2/M cell cycle arrest in human colorectal cancer cellsInt. J. Cancer91(3)393-401(2001)
| Cas No. | 1279033-22-5 | SDF | |
| Canonical SMILES | C[C@H](C1)[C@](C(C2=C3OC)=O)(OC2=C(C(OC)=C3)Cl)C(OC([2H])([2H])[2H])=CC1=O | ||
| Formula | C17H14ClD3O6 | M.Wt | 355.8 |
| الذوبان | Acetonitrile: soluble,DMF: soluble,DMSO: soluble,Methanol: soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.8106 mL | 14.0528 mL | 28.1057 mL |
| 5 mM | 0.5621 mL | 2.8106 mL | 5.6211 mL |
| 10 mM | 0.2811 mL | 1.4053 mL | 2.8106 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 40 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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