الصفحة الرئيسية>>Signaling Pathways>> Stem Cell>> Smoothened>>GSA 10

GSA 10

رقم الكتالوجGC14640

GSA 10 هو ناهض قوي لمستقبلات Smoothened (Smo) مع EC50 من 1.2 ميكرومتر. GSA 10 هو مشتق جديد للكينولين كاربوكساميد. يعمل GSA 10 في Smo لتعزيز تمايز الخلايا السلفية الوسيطة متعددة القدرات في بانيات العظم. يتوسط GSA 10 إشارات القنفذ (Hh) التي قد يكون لها اهتمامات بحثية في الطب التجديدي لمرض السرطان.

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GSA 10 التركيب الكيميائي

Cas No.: 300833-95-8

الحجم السعر المخزون الكميّة
5mg
119٫00
متوفر
10mg
222٫00
متوفر
25mg
527٫00
متوفر
50mg
992٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Chemical Properties of GSA 10

Cas No. 300833-95-8 SDF
Chemical Name propyl 4-(1-hexyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carboxamido)benzoate
Canonical SMILES CCCCCCN1C2=CC=CC=C2C(O)=C(C1=O)C(NC3=CC=C(C(OCCC)=O)C=C3)=O
Formula C26H30N2O5 M.Wt 450.53
الذوبان DMF: 1 mg/ml Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of GSA 10

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.2196 mL 11.098 mL 22.1961 mL
5 mM 0.4439 mL 2.2196 mL 4.4392 mL
10 mM 0.222 mL 1.1098 mL 2.2196 mL
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In vivo Formulation Calculator (Clear solution) of GSA 10

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

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Average Rating: 5 ★★★★★ (Based on Reviews and 2 reference(s) in Google Scholar.)

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