Huwentoxin XVI |
| رقم الكتالوجGC18027 |
Huwentoxin XVI ، مسكن ، هو مضاد لقنوات الكالسيوم من النوع N للثدييات من النوع N القابل للانعكاس والانتقائية (IC50 ~ 60 نانومتر) من الرتيلاء الصيني Ornithoctonus huwena
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1600543-88-1
Sample solution is provided at 25 µL, 10mM.
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Huwentoxin XVI(HWTX-XVI ) is composed of 39 amino acid residues including six cysteines. HWTX-XVI is a novel neurotoxin from the venom of Chinese tarantula O. huwena. and specificially block N-type calcium channels. [1]
N-type calcium channels are often highly expressed both in dorsal root ganglia cell bodies and in the synaptic terminals projecting to dorsal horn of the spinal cord N-type calcium channels play important roles in the control of neurotransmission release and transmission of pain signals to the central nervous system.[2]
Electrophysiological assay indicated that HWTX-XVI specifically inhibited N-type calcium channels in rat dorsal root ganglion cells. HWTX-XVI specifically inhibits GVIA sensitive, N-type calcium channels in rat DRG cells.[1]
HWTX-XVI could almost completely block the twitch response of rat vas deferens to low-frequency electrical stimulation. HWTX-XVI ‘s analgesic effects, non-toxic and complete reversibility make it an interesting tool for developing novel drugs for the treatment of N-type calcium channel-related diseases.[1,2]
References:
[1] Deng M, Luo X, Xiao Y etal. , Huwentoxin-XVI, an analgesic, highly reversible mammalian N-type calcium channel antagonist from Chinese tarantula Ornithoctonus huwena. Neuropharmacology. 2014 Apr;79:657-67.
[2] Liu Z, Dai J, Dai L etal. , Function and solution structure of Huwentoxin-X, a specific blocker of N-type calcium channels, from the Chinese bird spider Ornithoctonus huwena. J Biol Chem. 2006 Mar 31;281(13):8628-35.
| Cas No. | 1600543-88-1 | SDF | |
| Canonical SMILES | CCC(C(/N=C(O)/C(N)CSSCC(/N=C(O)/C(N=C(O)C(N=C(O)C1CCCN12)CCCNC(N)=N)CSSCC(/N=C(O)/C(/N=C(O)/C(/N=C(O)/C(/N=C(O)\C(/N=C(O)/C(/N=C(O)/C(/N=C(O)/C(/N=C(O)/C/N=C(O)/C(/N=C(O)/C(/N=C(O)/C(/N=C(O)/C3CCCN34)C(O)C)CC(C)C)CC5=CN=CN5)C(CC)C)CC6=CNC7=CC=CC=C67)CC8=C | ||
| Formula | C196H292N50O56S6 | M.Wt | 4437.11 |
| الذوبان | Soluble to 1 mg/ml in Water | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 225.4 μL | 1.1269 mL | 2.2537 mL |
| 5 mM | 45.1 μL | 225.4 μL | 450.7 μL |
| 10 mM | 22.5 μL | 112.7 μL | 225.4 μL |
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- Purity: >98.00%
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