Implitapide (AEGR 427) |
رقم الكتالوجGC33766 |
Implitapide (AEGR 427) (AEGR 427) هو مثبط لبروتين نقل الدهون الثلاثية (MTP).
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Cas No.: 177469-96-4
Sample solution is provided at 25 µL, 10mM.
Implitapide (AEGR 427) is a microsomal triglyceride transfer protein (MTP) inhibitor.
Implitapide suppresses MTP activity using a recombinant human form complexed with protein disulphide isomerase (IC50=10 nM) and inhibit secretion of apoB-containing very low-density lipoprotein (VLDL)-like lipoproteins from a human hepatoma cell (HepG2) with an IC50 value of 1.1 nM[1].
Implitapide (3.2 mg/kg/d) significantly reduces the plasma lipid levels to nearly or below the chow diet (CD) level at 4 and 8 weeks of treatment (p
[1]. Ueshima K, et al. Implitapide, a microsomal triglyceride transfer protein inhibitor, reduces progression of atherosclerosis in apolipoprotein E knockout mice fed a Western-type diet: involvement of the inhibition of postprandial triglyceride elevation. Biol Pharm Bull. 2005 Feb;28(2):247-52.
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