الصفحة الرئيسية>>Signaling Pathways>> MAPK Signaling>> ERK>>JWG-071

JWG-071

رقم الكتالوجGC38804

JWG-071 هو أول مسبار كيميائي انتقائي للكيناز تم الإبلاغ عنه لـ ERK5JWG-071 يحسن نشاط ERK5 وانتقائية BRD4سيكون JWG-071 مسبارًا كيميائيًا تمس الحاجة إليه لفك تشابك علم الصيدلة ERK5 و BRD4

Products are for research use only. Not for human use. We do not sell to patients.

JWG-071 التركيب الكيميائي

Cas No.: 2250323-50-1

الحجم السعر المخزون الكميّة
10 mM * 1 mL in DMSO
97٫00
متوفر
1mg
23٫00
متوفر
5mg
72٫00
متوفر
10mg
117٫00
متوفر
25mg
229٫00
متوفر

Tel:(909) 407-4943 Email: sales@glpbio.com


مراجعات العميل

بناء على آراء العملاء.

  • GlpBio Citations

    GlpBio Citations
  • Bioactive Compounds Premium Provider

    Bioactive Compounds Premium Provider

Sample solution is provided at 25 µL, 10mM.

Description of JWG-071

JWG-071 is the first reported kinase-selective chemical probe for ERK5. JWG-071 improves ERK5 activity and BRD4 selectivity. JWG-071 will be a much-needed chemical probe for deconvoluting ERK5 and BRD4 pharmacology[1].

JWG-071 inhibits ERK5 and LRRK2 with IC50 of 88 and 109 nM, respectively[1].

[1]. Wang J, et al. Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinonesas Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 2018 Sep 21;13(9):2438-2448

Chemical Properties of JWG-071

Cas No. 2250323-50-1 SDF
Canonical SMILES COC1=CC(C(N2CCC(N3CCN(C)CC3)CC2)=O)=CC=C1NC4=NC=C(N(C)C5=O)C(N(C6=CC=CC=C65)C(C)CC)=N4
Formula C34H44N8O3 M.Wt 612.76
الذوبان Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of JWG-071

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.632 mL 8.1598 mL 16.3196 mL
5 mM 0.3264 mL 1.632 mL 3.2639 mL
10 mM 0.1632 mL 0.816 mL 1.632 mL
  • حاسبة المولارية

  • حاسبة التخفيف

  • Molecular Weight Calculator

كتلة
=
تركيز
x
مقدار
x
ميغاواط *
 
 
 
** عند إعداد حلول المخزون، دائمًا استخدم الوزن الجزيئي الخاص بالدفعة للمنتج على ملصق القارورة MSDS / CoA (متوفر عبر الإنترنت).

احسب

In vivo Formulation Calculator (Clear solution) of JWG-071

Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)

mg/kg g μL

Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)

% DMSO % % Tween 80 % ddH2O
%DMSO %

Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Product Documents

Quality Control & SDS

View current batch:

مراجعات

Review for JWG-071

Average Rating: 5 ★★★★★ (Based on Reviews and 5 reference(s) in Google Scholar.)

5 Star
100%
4 Star
0%
3 Star
0%
2 Star
0%
1 Star
0%
Review for JWG-071

GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.

Required fields are marked with *

You may receive emails regarding this submission. Any emails will include the ability to opt-out of future communications.