Mitoquinol |
| رقم الكتالوجGC44205 |
ميتوكوينول هو مشتق يوبيكينون يتراكم بشكل خاص في الميتوكندريا نظرًا للارتباط التضافري لثلاثية فنيل فسفات الكاتيون.
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Cas No.: 845959-55-9
Sample solution is provided at 25 µL, 10mM.
Mitoquinol is a ubiquinone derivative that specifically accumulates in mitochondria due to the covalent attachment of the cation triphenylphosphonium. [1 It functions as an antioxidant, preventing lipid peroxidation-induced apoptosis and protecting mitochondria from oxidative damage.[2]
Reference:
[1]. Kelso, G.F., Porteous, C.M., Coulter, C.V., et al. Selective targeting of a redox-active ubiquinone to mitochondria within cells. Antioxidant and antiapoptotic properties. J. Biol. Chem. 276(7), 4588-4596 (2001).
[2]. O'Malley, Y., Fink, B.D., Ross, N.C., et al. Reactive oxygen and targeted antioxidant administration in endothelial cell mitochondria. J. Biol. Chem. 281(52), 39766-39775 (2006).
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