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MRT-81

رقم الكتالوجGC63336

MRT-81 هو مضاد قوي لمستقبلات الإنسان والقوارض المصقول (Smo) ، بقيمة IC 50 تبلغ 41 نانومتر في خلايا Shh-light2MRT-81 له نشاط قوي في تثبيط القنفذيمكن استخدام MRT-81 في أبحاث السرطان

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MRT-81 التركيب الكيميائي

Cas No.: 1263132-08-6

الحجم السعر المخزون الكميّة
5 mg
211٫00
متوفر
10 mg
336٫00
متوفر
25 mg
672٫00
متوفر
50 mg
1069٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of MRT-81

MRT-81 is a potent antagonist of human and rodent smoothened Smo receptors, with an IC50 value of 41 nM in the Shh-light2 cells. MRT-81 has potent hedgehog inhibiting activity. MRT-81 can be used for the research of cancer[1].

MRT-81 inbihits the differentiation of the mesenchymal pluripotent C3H10T1/2 cells into alkaline phosphatasepositive osteoblasts induced by the Smo agonist SAG (0.1 μM), with an IC50 value of 64 nM[1].MRT-81 (1-1000 nM) is a potent antagonist of SAG (0.01 μM)-induced proliferation of rat granule cell precursors (GCPs) with an IC50 less than 10 nM[1].MRT-81 (0, 0.1, 1, 10, 30, 100, 300, 1000 nM; 2 h; 37 °C) blocks BODIPY-cyclopamine (5 nM) binding to hSmo in a dose-dependent manner with an IC50 of 63 nM in HEK-hSmo cells[1].

[1]. Solinas A, et al. Acylthiourea, acylurea, and acylguanidine derivatives with potent hedgehog inhibiting activity. J Med Chem. 2012 Feb 23;55(4):1559-71.

Chemical Properties of MRT-81

Cas No. 1263132-08-6 SDF
Formula C31H29N3O5S M.Wt 555.64
الذوبان Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of MRT-81

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.7997 mL 8.9986 mL 17.9973 mL
5 mM 0.3599 mL 1.7997 mL 3.5995 mL
10 mM 0.18 mL 0.8999 mL 1.7997 mL
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In vivo Formulation Calculator (Clear solution) of MRT-81

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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