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NSC 617145

رقم الكتالوجGC18507

NSC 617145 هو مثبط هليكاز متلازمة ويرنر الانتقائي (WRN) مع قيمة IC50 تبلغ 230 نانومتريثبط NSC 617145 WRN ATPase ، ويؤدي إلى حدوث فواصل مزدوجة (DSB) وتشوهات الكروموسوماتيظهر NSC 617145 انتقائيًا لـ WRN عبر طائرات BLM و FANCJ و ChlR1 و RecQ و UvrD

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NSC 617145 التركيب الكيميائي

Cas No.: 203115-63-3

الحجم السعر المخزون الكميّة
1mg
30٫00
متوفر
5mg
79٫00
متوفر
10mg
119٫00
متوفر
25mg
258٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Description of NSC 617145

NSC 617145 is an inhibitor of WRN helicase (IC50 = 230 nM) that inhibits the ATPase, but not exonuclease, activity of WRN helicase in a concentration-dependent manner[1] . It is selective for WRN over BLM, FANCJ, ChlR1, RecQ, and UvrD helicases, only exhibiting 7% inhibition of RECQ1 at a concentration of 5 uM. NSC 617145 inhibits growth of HeLa cells via formation of DNA double strand breaks (DSBs) and induction of apoptosis in a WRN helicase-dependent manner. NSC 617145 also acts synergistically with mitomycin C to inhibit growth as well as induce DSBs and chromosomal abnormalities in Fanconia-anemia deficient (FA-D2-/-) cells.

Reference:
[1]. Aggarwal, M., Banerjee, T., Sommers, J.A., et al. Werner syndrome helicase has a critical role in DNA damage responses in the absence of a functional fanconi anemia pathway. Cancer Res. 73(17), 5497-5507 (2013).

Chemical Properties of NSC 617145

Cas No. 203115-63-3 SDF
Chemical Name 1,1'-(2,2-dimethyl-1,3-propanediyl)bis[3,4-dichloro-1H-pyrrole-2,5-dione
Canonical SMILES CC(CN(C(C(Cl)=C1Cl)=O)C1=O)(C)CN2C(C(Cl)=C(Cl)C2=O)=O
Formula C13H10Cl4N2O4 M.Wt 400
الذوبان 1mg/mL in DMSO, 2mg/mL in DMF Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of NSC 617145

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 2.5 mL 12.5 mL 25 mL
5 mM 0.5 mL 2.5 mL 5 mL
10 mM 0.25 mL 1.25 mL 2.5 mL
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In vivo Formulation Calculator (Clear solution) of NSC 617145

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 1 reference(s) in Google Scholar.)

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