الصفحة الرئيسية>>Signaling Pathways>> Stem Cell>> Oct3/4>>OAC1

OAC1

رقم الكتالوجGC10151

OAC1 هو منشط قوي Oct4ينشط OAC1 محفزات Oct4 و Nanog ويعزز تكوين الخلايا الجذعية المحفزة (iPSC)ينشط OAC1 OCT4 من خلال تنظيم تعبير HOXB4يزيد OAC1 من نسخ ثلاثي Oct4-Nanog-Sox2 و Tet1يسهل OAC1 إعادة برمجة الخلايا من خلال تعزيز الكفاءة وتقصير وقت إعادة البرمجة

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OAC1 التركيب الكيميائي

Cas No.: 300586-90-7

الحجم السعر المخزون الكميّة
10mM (in 1mL DMSO)
41٫00
متوفر
10mg
70٫00
متوفر
50mg
253٫00
متوفر

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Sample solution is provided at 25 µL, 10mM.

Description of OAC1

OAC1 is an activator of Oct4 [1].

Octamer-binding transcription factor 4 (Oct4) is a regulator of embryonic stem cell (ESC) pluripotency and the reprogramming process. High expression of Oct4 results in differentiation of ESCs along the mesodermal and primitive endodermal lineages. However, low expression of Oct4 leads to differentiation of ESCs into trophectodermal cells [1].

OAC1 is an Oct4 activator. In luciferase reporter assays, OAC1 activated both human Oct4 and Nanog promoter-driven luciferase reporter genes. In mouse embryonic fibroblasts (MEFs) with the 4F reprogramming quartet Oct4, Klf4, Sox2, and c-Myc, OAC1 enhanced reprogramming efficiency and increased the number of colonies with ESC-like morphology by twofold or more. Also, OAC1 increased induced pluripotent stem cells (iPSC)-like colonies. OAC1 had no effects on the Wnt signaling and p53-p21 expression. In MEFs, OAC1 activated the expression of endogenous Oct4 and Nanog. Also, OAC1 increased the expression of Sox2 and Tet1 [1].

Reference:
[1].  Li W, Tian E, Chen ZX, et al. Identification of Oct4-activating compounds that enhance reprogramming efficiency. Proc Natl Acad Sci U S A, 2012, 109(51): 20853-20858.

Chemical Properties of OAC1

Cas No. 300586-90-7 SDF
Chemical Name N-(1H-pyrrolo[2,3-c]pyridin-5-yl)benzamide
Canonical SMILES C1=CC=C(C=C1)C(=O)NC2=NC=C3C(=C2)C=CN3
Formula C14H11N3O M.Wt 237.26
الذوبان ≥ 9.9mg/mL in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table of OAC1

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 4.2148 mL 21.0739 mL 42.1479 mL
5 mM 0.843 mL 4.2148 mL 8.4296 mL
10 mM 0.4215 mL 2.1074 mL 4.2148 mL
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In vivo Formulation Calculator (Clear solution) of OAC1

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 6 reference(s) in Google Scholar.)

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